Izumerogant

Names

[ Name ]:
Izumerogant

Biological Activity

[Description]:

Izumerogant is an inverse agonist of retinoid-related orphan receptor-gamma (RORγ). Izumerogant (compound 123) also potently inhibits IL-17A, IL-17F and IFN-γ activity with IC50s <50 nM[1][2].

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> ROR

Research Areas >> Others

[References]

[1]. F Jakob, et al. Isoxazole-pyrazole derivatives and related compounds as IL-17 and IFN-γ inhibitors for treating autoimmune diseases and chronic inflammation: World Intellectual Property Organization, WO2019048541. 2019-03-14.

[2]. WHO Drug Information-World Health Organization (WHO).

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₂H₁₈ClF₄N₅O₂

[ Molecular Weight ]:
495.86

Related Compounds

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