H-D-Glu(Trp-OH)-OH

Modify Date: 2024-01-10 18:44:25

H-D-Glu(Trp-OH)-OH structure	Common Name	H-D-Glu(Trp-OH)-OH
	CAS Number	229305-39-9	Molecular Weight	333.33900
	Density	1.428g/cm3	Boiling Point	737.3ºC at 760 mmHg
	Molecular Formula	C₁₆H₁₉N₃O₅	Melting Point	N/A
	MSDS	N/A	Flash Point	399.7ºC

Use of H-D-Glu(Trp-OH)-OH

Golotimod (SCV-07), an immunomodulating peptide with antimicrobial activity, significantly increases the efficacy of antituberculosis therapy, stimulates thymic and splenic cell proliferation, and improves macrophage function. Golotimod (SCV-07) inhibits STAT3 signaling and modulates the duration and severity of oral mucositis in animal models that received radiation or a combination of radiation and Cisplatin. Golotimod (SCV-07) is a potential therapeutic for recurrent genital herpes simplex virus type 2 (HSV-2)[1][2][3].

Name	(2R)-2-amino-5-[[(1S)-1-carboxy-2-(1H-indol-3-yl)ethyl]amino]-5-oxopentanoic acid
Synonym	More Synonyms

Description	Golotimod (SCV-07), an immunomodulating peptide with antimicrobial activity, significantly increases the efficacy of antituberculosis therapy, stimulates thymic and splenic cell proliferation, and improves macrophage function. Golotimod (SCV-07) inhibits STAT3 signaling and modulates the duration and severity of oral mucositis in animal models that received radiation or a combination of radiation and Cisplatin. Golotimod (SCV-07) is a potential therapeutic for recurrent genital herpes simplex virus type 2 (HSV-2)[1][2][3].
Related Catalog	Signaling Pathways >> Stem Cell/Wnt >> STAT Signaling Pathways >> Anti-infection >> HSV Research Areas >> Infection Signaling Pathways >> JAK/STAT Signaling >> STAT Research Areas >> Inflammation/Immunology Signaling Pathways >> Anti-infection >> Bacterial
Target	STAT3[1]
References	[1]. Rose WA 2nd, et al. An immunomodulating dipeptide, SCV-07, is a potential therapeutic for recurrent genital herpes simplex virus type 2 (HSV-2). Int J Antimicrob Agents. 2008 Sep;32(3):262-6. [2]. Geiger JL, et al. The STAT3 pathway as a therapeutic target in head and neck cancer: Barriers and innovations. Oral Oncol. 2016 May;56:84-92. [3]. Watkins B, et al. Attenuation of radiation- and chemoradiation-induced mucositis using gamma-D-glutamyl-L-tryptophan (SCV-07). Oral Dis. 2010 Oct;16(7):655-60.

Density	1.428g/cm3
Boiling Point	737.3ºC at 760 mmHg
Molecular Formula	C₁₆H₁₉N₃O₅
Molecular Weight	333.33900
Flash Point	399.7ºC
Exact Mass	333.13200
PSA	145.51000
LogP	1.56310
Vapour Pressure	7.99E-23mmHg at 25°C
Index of Refraction	1.659

SCV-07

Golotimod

DC Chemicals Limited
China
Product Name: Golotimod (SCV-07)
Price: $400.0/100mg $700.0/250mg $1300.0/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Zhejiang Hangyu API Co., Ltd
China
Product Name: H-D-Glu(Trp-OH)-OH
Price: $Inquiry/1kg
Purity: 99.0%
Stocking Period: 1 Day
Contact: Vinnie

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