CL2 Linker
Modify Date: 2025-09-18 20:30:32
CL2 Linker structure
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Common Name | CL2 Linker | ||
|---|---|---|---|---|
| CAS Number | 2270986-66-6 | Molecular Weight | 1426.61 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C68H103N11O22 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of CL2 LinkerCL2 Linker is an ADC linker. CL2-SN-38 and CL2A-SN-38 are equivalent in drug substitution (~6), cell binding (Kd ~1.2 nM), cytotoxicity (IC50 ~2.2 nM), and serum stability in vitro (t1/2 ~20 hours)[1][2]. |
| Name | CL2 Linker |
|---|
| Description | CL2 Linker is an ADC linker. CL2-SN-38 and CL2A-SN-38 are equivalent in drug substitution (~6), cell binding (Kd ~1.2 nM), cytotoxicity (IC50 ~2.2 nM), and serum stability in vitro (t1/2 ~20 hours)[1][2]. |
|---|---|
| Related Catalog | |
| Target |
Alkyl/ether |
| References |
| Molecular Formula | C68H103N11O22 |
|---|---|
| Molecular Weight | 1426.61 |
| InChIKey | BGFZCTPREVDQQQ-UHFFFAOYSA-N |
| SMILES | CN(CCN(C)C(=O)OCc1ccc(NC(=O)C(CCCCNC(=O)OC(C)(C)C)NC(=O)C(Cc2ccccc2)NC(=O)CCOCCOCCOCCOCCOCCOCCOCCOCCn2cc(CNC(=O)CCCCCN3C(=O)C=CC3=O)nn2)cc1)C(=O)OCC(=O)CO |