CL2 Linker

Names

[ CAS No. ]:
2270986-66-6

[ Name ]:
CL2 Linker

Biological Activity

[Description]:

CL2 Linker is an ADC linker. CL2-SN-38 and CL2A-SN-38 are equivalent in drug substitution (~6), cell binding (Kd ~1.2 nM), cytotoxicity (IC50 ~2.2 nM), and serum stability in vitro (t1/2 ~20 hours)[1][2].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker
Research Areas >> Inflammation/Immunology

[Target]

Alkyl/ether


[References]

[1]. Moon SJ, et al. Antibody conjugates of 7-ethyl-10-hydroxycamptothecin (SN-38) for targeted cancer chemotherapy. J Med Chem. 2008 Nov 13;51(21):6916-26.

[2]. Cardillo TM, et al. Humanized anti-Trop-2 IgG-SN-38 conjugate for effective treatment of diverse epithelial cancers: preclinical studies in human cancer xenograft models and monkeys. Clin Cancer Res. 2011 May 15;17(10):3157-69.

Chemical & Physical Properties

[ Molecular Formula ]:
C68H103N11O22

[ Molecular Weight ]:
1426.61

Related Compounds