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CL2-SN-38

Names

[ CAS No. ]:
1036969-20-6

[ Name ]:
CL2-SN-38

Biological Activity

[Description]:

CL2-SN-38 is a part of the antibody drug conjugate (ADC), can conjugate with the anti-Trop-2-humanized antibody hRS7. The anti-Trop-2 hRS7-CL2A-SN-38 ADC provides significant and specific antitumor effects against a range of human solid tumor types[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Antibody-drug Conjugate >> Drug-Linker Conjugates for ADC

[References]

[1]. Cardillo TM, et al. Humanized anti-Trop-2 IgG-SN-38 conjugate for effective treatment of diverse epithelial cancers: preclinical studies in human cancer xenograft models and monkeys. Clin Cancer Res. 2011 May 15;17(10):3157-69.

Chemical & Physical Properties

[ Molecular Formula ]:
C83H107N11O23

[ Molecular Weight ]:
1626.80

Related Compounds