RU-521
Modify Date: 2024-01-01 19:54:44
RU-521 structure
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Common Name | RU-521 | ||
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| CAS Number | 2262452-06-0 | Molecular Weight | 415.23 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C19H12Cl2N4O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of RU-521RU.521 (RU320521) is a potent dsDNA and cGAS inhibitor with an IC50 of 700 nM for dsDNA. RU.521 inhibits cGAS-mediated interferon upregulation and suppresses dsDNA-dependent activation. RU.521 is active and selective in cellular assays of cyclic GMP-AMP synthase-mediated signaling and reduces constitutive expression of interferon in macrophages from a mouse model of Aicardi-Goutières syndrome (AGS)[1]. |
| Name | RU.521 |
|---|
| Description | RU.521 (RU320521) is a potent dsDNA and cGAS inhibitor with an IC50 of 700 nM for dsDNA. RU.521 inhibits cGAS-mediated interferon upregulation and suppresses dsDNA-dependent activation. RU.521 is active and selective in cellular assays of cyclic GMP-AMP synthase-mediated signaling and reduces constitutive expression of interferon in macrophages from a mouse model of Aicardi-Goutières syndrome (AGS)[1]. |
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| Related Catalog | |
| Target |
IC50: 700 nM (dsDNA)[1] |
| References |
| Molecular Formula | C19H12Cl2N4O3 |
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| Molecular Weight | 415.23 |
| Storage condition | -20°C |
| Hazard Codes | Xi |
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