2262452-06-0

2262452-06-0 structure

Name: RU-521
Chemical Name: RU.521
CAS Number: 2262452-06-0
Molecular Formula: C₁₉H₁₂Cl₂N₄O₃
Molecular Weight: 415.23
Catalog: Research Areas Others
Create Date: 2019-09-06 20:40:18
Modify Date: 2024-01-01 19:54:44
RU.521 (RU320521) is a potent dsDNA and cGAS inhibitor with an IC50 of 700 nM for dsDNA. RU.521 inhibits cGAS-mediated interferon upregulation and suppresses dsDNA-dependent activation. RU.521 is active and selective in cellular assays of cyclic GMP-AMP synthase-mediated signaling and reduces constitutive expression of interferon in macrophages from a mouse model of Aicardi-Goutières syndrome (AGS)[1].

Name	RU.521

Description	RU.521 (RU320521) is a potent dsDNA and cGAS inhibitor with an IC50 of 700 nM for dsDNA. RU.521 inhibits cGAS-mediated interferon upregulation and suppresses dsDNA-dependent activation. RU.521 is active and selective in cellular assays of cyclic GMP-AMP synthase-mediated signaling and reduces constitutive expression of interferon in macrophages from a mouse model of Aicardi-Goutières syndrome (AGS)[1].
Related Catalog	Research Areas >> Others
Target	IC50: 700 nM (dsDNA)[1]
References	[1]. Vincent J, et al. Small molecule inhibition of cGAS reduces interferon expression in primary macrophages from autoimmune mice. Nat Commun. 2017 Sep 29;8(1):750.

Hazard Codes	Xi