| Description |
Malacidin A is the calcium-dependent antibiotic (CDAs). Malacidin A is highly active against many antibiotic-resistant pathogens, particularly Gram-positive bacteria[1][2].
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| Related Catalog |
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| In Vitro |
Malacidin A has antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA) in a calcium-dependent manner[1]. Malacidin A (100-250 µg/mL) has broadly active against Gram-positive bacteria including multidrug-resistant pathogens and bacteria resistant to mechanistically diverse, clinically used antibiotics with MIC values of 0.1-2.0 µg/mL[1].
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| In Vivo |
Malacidin A (4 mg/kg; apply over the wound) has antibacterial activity and inhibits bacterial load in cutaneous wound infection mice[1]. Animal Model: Male Sprague Dawley rats (8 weeks old) with cutaneous wound infection model[1] Dosage: 4 mg/kg Administration: Apply over the wound Result: Had no observed bacterial burdens in the wounds.
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