Malacidin A

Names

[ Name ]:
Malacidin A

Biological Activity

[Description]:

Malacidin A is the calcium-dependent antibiotic (CDAs). Malacidin A is highly active against many antibiotic-resistant pathogens, particularly Gram-positive bacteria[1][2].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Bacterial

[In Vitro]

Malacidin A has antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA) in a calcium-dependent manner[1]. Malacidin A (100-250 µg/mL) has broadly active against Gram-positive bacteria including multidrug-resistant pathogens and bacteria resistant to mechanistically diverse, clinically used antibiotics with MIC values of 0.1-2.0 µg/mL[1].

[In Vivo]

Malacidin A (4 mg/kg; apply over the wound) has antibacterial activity and inhibits bacterial load in cutaneous wound infection mice[1]. Animal Model: Male Sprague Dawley rats (8 weeks old) with cutaneous wound infection model[1] Dosage: 4 mg/kg Administration: Apply over the wound Result: Had no observed bacterial burdens in the wounds.

Chemical & Physical Properties

[ Molecular Formula ]:
C₅₆H₈₈N₁₂O₂₀

[ Molecular Weight ]:
1249.37

Related Compounds

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