SHIP2-IN-1

Modify Date: 2025-08-25 16:55:04

SHIP2-IN-1 Structure
SHIP2-IN-1 structure
 Common Name SHIP2-IN-1
CAS Number 2252247-80-4 Molecular Weight 379.22
Density N/A Boiling Point N/A
Molecular Formula C17H13Cl2FN4O Melting Point N/A
MSDS N/A Flash Point N/A

 Use of SHIP2-IN-1


SHIP2-IN-1 is a potent SHIP2 inhibitor, inhibits SHIP2 activity, with an IC50 of 2 µM. SHIP2-IN-1 blocks GSK3β activation by phosphorylation at the Ser9 residue. SHIP2-IN-1 is used in the research of Alzheimer’s disease[1].

 Names

Name SHIP2-IN-1

 SHIP2-IN-1 Biological Activity

Description SHIP2-IN-1 is a potent SHIP2 inhibitor, inhibits SHIP2 activity, with an IC50 of 2 µM. SHIP2-IN-1 blocks GSK3β activation by phosphorylation at the Ser9 residue. SHIP2-IN-1 is used in the research of Alzheimer’s disease[1].
Related Catalog
Target

IC50: 2 µM (SHIP2)[1]

In Vitro SHIP2-IN-1 (Compound 43; 10 µM) significantly inhibits PI(3,4)P2 production in HT22 cells[1].
References

[1]. Lim JW, et al. Identification of crizotinib derivatives as potent SHIP2 inhibitors for the treatment of Alzheimer's disease. Eur J Med Chem. 2018 Sep 5;157:405-422.

 Chemical & Physical Properties

Molecular Formula C17H13Cl2FN4O
Molecular Weight 379.22
InChIKey ATPYDXUUBCDYKQ-SECBINFHSA-N
SMILES CC(Oc1cncc(-c2cnc(N)nc2)c1)c1c(Cl)ccc(F)c1Cl
Storage condition -20°C
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Chemsrc provides SHIP2-IN-1(CAS#:2252247-80-4) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of SHIP2-IN-1 are included as well.>> amp version: SHIP2-IN-1

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