SHIP2-IN-1

Names

[ Name ]:
SHIP2-IN-1

Biological Activity

[Description]:

SHIP2-IN-1 is a potent SHIP2 inhibitor, inhibits SHIP2 activity, with an IC50 of 2 µM. SHIP2-IN-1 blocks GSK3β activation by phosphorylation at the Ser9 residue. SHIP2-IN-1 is used in the research of Alzheimer’s disease[1].

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphatase

Research Areas >> Neurological Disease

[Target]

IC50: 2 µM (SHIP2)[1]

[In Vitro]

SHIP2-IN-1 (Compound 43; 10 µM) significantly inhibits PI(3,4)P2 production in HT22 cells[1].

[References]

[1]. Lim JW, et al. Identification of crizotinib derivatives as potent SHIP2 inhibitors for the treatment of Alzheimer's disease. Eur J Med Chem. 2018 Sep 5;157:405-422.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₇H₁₃Cl₂FN₄O

[ Molecular Weight ]:
379.22

[ Storage condition ]:
-20°C

Related Compounds

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