Pirepemat fumarate

Modify Date: 2025-08-25 07:30:27

Pirepemat fumarate Structure
Pirepemat fumarate structure
 Common Name Pirepemat fumarate
CAS Number 2251806-70-7 Molecular Weight 329.30
Density N/A Boiling Point N/A
Molecular Formula C15H17F2NO5 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Pirepemat fumarate


Pirepemat (IRL752) fumarate is a corticalpreferring catecholamine- and cognition-promoting agent. Pirepemat fumarate is used for the study of Parkinson's disease[1][2].

 Names

Name Pirepemat fumarate

 Pirepemat fumarate Biological Activity

Description Pirepemat (IRL752) fumarate is a corticalpreferring catecholamine- and cognition-promoting agent. Pirepemat fumarate is used for the study of Parkinson's disease[1][2].
Related Catalog
In Vitro IRL752 fumarate displays its highest in vitro affinities for 5-HT and NA-related targets[2].
In Vivo IRL752 (3.7-100 µmol/kg, s.c.) fumarate has no significant effect on acute hyper-dopaminergic or hypo-glutamatergic motor responses, but reverses deficits resulting from hypomonoaminergic function[2]. Animal Model: Normal rats[2] Dosage: 3.7-100 µmol/kg Administration: S.c., 30 min prior to testing Result: Induced dose-dependent and regio-selective alterations in brain monoamine transmission indices and gene expression.
References

[1]. Ipsen and IRLAB Enter Exclusive Worldwide Licensing Agreement Aimed to Improve the Lives of People Living with Parkinson's Disease.

[2]. S Hjorth, et al. (3 S)-3-(2,3-difluorophenyl)-3-methoxypyrrolidine (IRL752) -a Novel Cortical-Preferring Catecholamine Transmission- and Cognition-Promoting Agent. J Pharmacol Exp Ther. 2020 Sep;374(3):404-419.

 Chemical & Physical Properties

Molecular Formula C15H17F2NO5
Molecular Weight 329.30
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