Pirepemat

Modify Date: 2024-01-14 16:18:16

Pirepemat Structure
Pirepemat structure
Common Name Pirepemat
CAS Number 1227638-29-0 Molecular Weight 213.22
Density 1.2±0.1 g/cm3 Boiling Point 276.2±40.0 °C at 760 mmHg
Molecular Formula C11H13F2NO Melting Point N/A
MSDS N/A Flash Point 120.8±27.3 °C

 Use of Pirepemat


Pirepemat (IRL752) is a corticalpreferring catecholamine- and cognition-promoting agent. Pirepemat (IRL752) is used for the study of Parkinson's disease[1][2].

 Names

Name Irl-752
Synonym More Synonyms

 Pirepemat Biological Activity

Description Pirepemat (IRL752) is a corticalpreferring catecholamine- and cognition-promoting agent. Pirepemat (IRL752) is used for the study of Parkinson's disease[1][2].
Related Catalog
In Vitro IRL752 displayed its highest in vitro affinities for 5-HT and NA-related targets[2].
In Vivo IRL752 (3.7-100 µmol/kg, s.c.) has no significant effect on acute hyper-dopaminergic or hypo-glutamatergic motor responses, but reversed deficits resulting from hypomonoaminergic function[2]. Animal Model: Normal rats[2]. Dosage: 3.7-100 µmol/kg. Administration: s.c., 30 min prior to testing. Result: Induced dose-dependent and regio-selective alterations in brain monoamine transmission indices and gene expression.
References

[1]. Ipsen and IRLAB Enter Exclusive Worldwide Licensing Agreement Aimed to Improve the Lives of People Living with Parkinson's Disease.

[2]. S Hjorth, et al. (3 S)-3-(2,3-difluorophenyl)-3-methoxypyrrolidine (IRL752) -a Novel Cortical-Preferring Catecholamine Transmission- and Cognition-Promoting Agent. J Pharmacol Exp Ther. 2020 Sep;374(3):404-419.

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 276.2±40.0 °C at 760 mmHg
Molecular Formula C11H13F2NO
Molecular Weight 213.22
Flash Point 120.8±27.3 °C
Exact Mass 213.096527
LogP 1.01
Vapour Pressure 0.0±0.6 mmHg at 25°C
Index of Refraction 1.515

 Synonyms

3-(2,3-Difluorophenyl)-3-methoxypyrrolidine
Irl-752
Pyrrolidine, 3-(2,3-difluorophenyl)-3-methoxy-
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