7-Chloro-3,4-dihydro-3-methyl-2H-1,2,4-benzothiadiazine 1,1-dioxide

Modify Date: 2025-08-25 13:14:43

7-Chloro-3,4-dihydro-3-methyl-2H-1,2,4-benzothiadiazine 1,1-dioxide Structure
7-Chloro-3,4-dihydro-3-methyl-2H-1,2,4-benzothiadiazine 1,1-dioxide structure
 Common Name 7-Chloro-3,4-dihydro-3-methyl-2H-1,2,4-benzothiadiazine 1,1-dioxide
CAS Number 22503-72-6 Molecular Weight 232.69
Density 1.4±0.1 g/cm3 Boiling Point 405.1±55.0 °C at 760 mmHg
Molecular Formula C8H9ClN2O2S Melting Point N/A
MSDS USA Flash Point 198.8±31.5 °C

 Use of 7-Chloro-3,4-dihydro-3-methyl-2H-1,2,4-benzothiadiazine 1,1-dioxide


IDRA 21 is a positive and orally active modulator of the AMPA receptor. IDRA 21 facilitates excitatory neurotransmission via GluR1/2 receptors. IDRA 21 has the potential for the research of cognitive/memory disorders, including those associated with aging[1].

 Names

Name IDRA 21,7-Chloro-3-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazineS,S-dioxide
Synonym More Synonyms

  Biological Activity

Description IDRA 21 is a positive and orally active modulator of the AMPA receptor. IDRA 21 facilitates excitatory neurotransmission via GluR1/2 receptors. IDRA 21 has the potential for the research of cognitive/memory disorders, including those associated with aging[1].
Related Catalog
References

[1]. Buccafusco JJ, et al. The effects of IDRA 21, a positive modulator of the AMPA receptor, on delayed matching performance by young and aged rhesus monkeys. Neuropharmacology. 2004 Jan;46(1):10-22. doi: 10.1016/j.neuropharm.2003.07.002.

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Boiling Point 405.1±55.0 °C at 760 mmHg
Molecular Formula C8H9ClN2O2S
Molecular Weight 232.69
Flash Point 198.8±31.5 °C
Exact Mass 232.007324
PSA 66.58000
LogP 0.77
Vapour Pressure 0.0±0.9 mmHg at 25°C
Index of Refraction 1.572

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Safety Phrases S24/25
RIDADR NONH for all modes of transport
HS Code 2933990090

 Precursor & DownStream

Precursor  2

DownStream  0

 Customs

HS Code 2933990090
Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Articles19

More Articles
Thermodynamics and structural analysis of positive allosteric modulation of the ionotropic glutamate receptor GluA2.

Biochem. J. 441(1) , 173-8, (2012)

Positive allosteric modulators of the ionotropic glutamate receptor-2 (GluA2) are promising compounds for the treatment of cognitive disorders, e.g. Alzheimer's disease. These modulators bind within t...

7-Chloro-3-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine S,S-dioxide: a partial modulator of AMPA receptor desensitization devoid of neurotoxicity.

Proc. Natl. Acad. Sci. U. S. A. 94(13) , 7053-8, (1997)

In cerebellar granule neurons of neonatal rats micromolar concentrations of 7-chloro-3-methyl-3,4-dihydro-2H-1,2, 4-benzothiadiazine S,S-dioxide (IDRA-21) and cyclothiazide, two negative modulators of...

IDRA-21, a positive AMPA receptor modulator, inhibits synaptic and extrasynaptic NMDA receptor mediated events in cultured cerebellar granule cells.

Neuropharmacology 46(8) , 1105-13, (2004)

IDRA-21 (7-chloro-3-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide) reduces alpha-amino-3-hydroxy-5-methylisoxazolepropionic acid (AMPA) receptors desensitisation in vitro and restores learn...

 Synonyms

7-chloro-3,4-dihydro-3-methyl-2h-1,2,4-benzothiadiazine 1,1-dioxide
7-Chloro-3-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine-S,S-dioxide
MFCD00270874
IDRA 21
2H-1,2,4-Benzothiadiazine, 7-chloro-3,4-dihydro-3-methyl-, 1,1-dioxide
Gadolinium chloride
7-Chloro-3-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide
7-CHLORO-3-METHYL-3,4-DIHYDRO-2H-1,2,4-BENZOTHIADIAZINE
The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.
Top Suppliers:I want be here

Get all suppliers and price by the below link:

7-Chloro-3,4-dihydro-3-methyl-2H-1,2,4-benzothiadiazine 1,1-dioxide suppliers

Price: ￥500/25 mg

Reference only. check more 7-Chloro-3,4-dihydro-3-methyl-2H-1,2,4-benzothiadiazine 1,1-dioxide price

Related Compounds: More...
N,N-dimethyl-4-(prop-2-enoyl)benzamide
2229286-22-8
1-(1,2-Diethoxyethyl)cyclopropan-1-amine
2743438-16-4
Ethyl 2-(2-(cyclopropanecarboxamido)pyridin-4-yl)-4-methoxythiazole-5-carboxylate
1801942-66-4
5'-(Propan-2-yl)-1',2'-dihydrospiro[cyclopropane-1,3'-indole]-2-amine
2138352-99-3
4'-Bromo-1',2'-dihydrospiro[cyclopropane-1,3'-indole]-3-amine
2138001-54-2
4',7'-Dichloro-1',2'-dihydrospiro[cyclopropane-1,3'-indole]-3-amine
2137847-07-3
7'-Chloro-1',2'-dihydrospiro[cyclopropane-1,3'-indole]-3-amine
2137847-09-5
(2S)-4-[2-(propan-2-yl)-1,3-thiazol-4-yl]butan-2-amine
2227777-22-0
2-Methyl-4-{pyrazolo[1,5-a]pyridin-3-yl}butan-2-amine
2228149-36-6
7-tert-butyl 3-chloromethyl 2-cyclopropyl-5H,6H,7H,8H-imidazo[1,2-a]pyrazine-3,7-dicarboxylate
2137704-34-6
Chemsrc provides CAS#:22503-72-6 MSDS, density, melting point, boiling point, structure, etc. Its name is 7-Chloro-3,4-dihydro-3-methyl-2H-1,2,4-benzothiadiazine 1,1-dioxide>> amp version: 7-Chloro-3,4-dihydro-3-methyl-2H-1,2,4-benzothiadiazine 1,1-dioxide

Home | MSDS/SDS Database Search | Journals | Product Classification | Biologically Active Compounds | Selling Leads | About Us | Disclaimer

Copyright © 2024 ChemSrc All Rights Reserved