Hydroxocobalamin Acetate

Modify Date: 2024-01-08 14:24:35

Hydroxocobalamin Acetate structure	Common Name	Hydroxocobalamin Acetate
	CAS Number	22465-48-1	Molecular Weight	1388.39000
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₆₄H₉₁CoN₁₃O₁₆P	Melting Point	>300ºC.
	MSDS	Chinese USA	Flash Point	N/A
	Symbol	GHS08	Signal Word	Warning

Use of Hydroxocobalamin Acetate

Hydroxocobalamin acetate is an injectable naturally occurring form of vitamin B12 with a favorable adverse effect profile, used as a dietary supplement in the treatment of vitamin B12 deficiency including pernicious anemia[1][2].

Name	Hydroxocobalamin Acetate
Synonym	More Synonyms

Description	Hydroxocobalamin acetate is an injectable naturally occurring form of vitamin B12 with a favorable adverse effect profile, used as a dietary supplement in the treatment of vitamin B12 deficiency including pernicious anemia[1][2].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Metabolic Disease
Target	The cobalt atom of hydroxocobalamin binds cyanide and nitric oxide (NO) and hydroxocobalamin attenuates vascular responses to NO in vitro[3].
References	[1]. Cheungpasitporn W, et al. High-dose hydroxocobalamin for vasoplegic syndrome causing false blood leak alarm. Clin Kidney J. 2017 Jun;10(3):357-362. [2]. Wang H, et al. Oral vitamin B12 versus intramuscular vitamin B12 for vitamin B12 deficiency. Cochrane Database Syst Rev. 2018 Mar 15;3:CD004655. [3]. Greenberg SS, et al. Hydroxocobalamin (vitamin B12a) prevents and reverses endotoxin-induced hypotension and mortality in rodents: role of nitric oxide. J Pharmacol Exp Ther. 1995 Apr;273(1):257-65.

Melting Point	>300ºC.
Molecular Formula	C₆₄H₉₁CoN₁₃O₁₆P
Molecular Weight	1388.39000
Exact Mass	1387.58000
PSA	490.17000
LogP	6.62930

Hydroxocobalamin Acetate MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GG3740000

CHEMICAL NAME :: Cobinamide, acetate (salt) hydroxide, dihydrogen phosphate (ester), inner salt, 3'-ester with 5,6-dimethyl-1-alpha-D-ribofuranosylbenzimidazole

CAS REGISTRY NUMBER :: 22465-48-1

LAST UPDATED :: 199409

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C64-H91-Co-N13-O16-P

MOLECULAR WEIGHT :: 1388.58

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,622,1982

Symbol	GHS08
Signal Word	Warning
Hazard Statements	H351
Precautionary Statements	P280
RIDADR	NONH for all modes of transport
RTECS	GG3740000

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The MMACHC gene product of the cblC complementation group, referred to as the cblC protein, catalyzes the in vitro and in vivo decyanation of cyanocobalamin (vitamin B(12)). We hypothesized that the c...

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B12 trafficking in mammals: A for coenzyme escort service.

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Many coenzymes are vitamins that are assimilated in mammals into their active form from precursors obtained from the diet. They are often both rare and reactive rendering the likelihood low that the c...

Hydroxocobalamin acetate

Vitamin B12a acetate

HYDROXOCOBALAMIN ACETATE