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22465-48-1

22465-48-1 structure
22465-48-1 structure
  • Name: Hydroxocobalamin Acetate
  • Chemical Name: Hydroxocobalamin Acetate
  • CAS Number: 22465-48-1
  • Molecular Formula: C64H91CoN13O16P
  • Molecular Weight: 1388.39000
  • Catalog: Research Areas Metabolic Disease
  • Create Date: 2018-06-20 18:30:28
  • Modify Date: 2025-08-22 21:31:38
  • Hydroxocobalamin acetate is an injectable naturally occurring form of vitamin B12 with a favorable adverse effect profile, used as a dietary supplement in the treatment of vitamin B12 deficiency including pernicious anemia[1][2].
Name Hydroxocobalamin Acetate
Synonyms Hydroxocobalamin acetate
Vitamin B12a acetate
HYDROXOCOBALAMIN ACETATE
Description Hydroxocobalamin acetate is an injectable naturally occurring form of vitamin B12 with a favorable adverse effect profile, used as a dietary supplement in the treatment of vitamin B12 deficiency including pernicious anemia[1][2].
Related Catalog
Target

The cobalt atom of hydroxocobalamin binds cyanide and nitric oxide (NO) and hydroxocobalamin attenuates vascular responses to NO in vitro[3].

References

[1]. Cheungpasitporn W, et al. High-dose hydroxocobalamin for vasoplegic syndrome causing false blood leak alarm. Clin Kidney J. 2017 Jun;10(3):357-362.

[2]. Wang H, et al. Oral vitamin B12 versus intramuscular vitamin B12 for vitamin B12 deficiency. Cochrane Database Syst Rev. 2018 Mar 15;3:CD004655.

[3]. Greenberg SS, et al. Hydroxocobalamin (vitamin B12a) prevents and reverses endotoxin-induced hypotension and mortality in rodents: role of nitric oxide. J Pharmacol Exp Ther. 1995 Apr;273(1):257-65.
Melting Point >300ºC.
Molecular Formula C64H91CoN13O16P
Molecular Weight 1388.39000
Exact Mass 1387.58000
PSA 490.17000
LogP 6.62930

CHEMICAL IDENTIFICATION

RTECS NUMBER :
GG3740000
CHEMICAL NAME :
Cobinamide, acetate (salt) hydroxide, dihydrogen phosphate (ester), inner salt, 3'-ester with 5,6-dimethyl-1-alpha-D-ribofuranosylbenzimidazole
CAS REGISTRY NUMBER :
22465-48-1
LAST UPDATED :
199409
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C64-H91-Co-N13-O16-P
MOLECULAR WEIGHT :
1388.58

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,622,1982
Symbol GHS08
GHS08
Signal Word Warning
Hazard Statements H351
Precautionary Statements P280
RIDADR NONH for all modes of transport
RTECS GG3740000
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