SS-208

Modify Date: 2024-01-20 18:37:20

SS-208 structure	Common Name	SS-208
	CAS Number	2245942-72-5	Molecular Weight	344.15
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₃H₁₁Cl₂N₃O₄	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of SS-208

SS-208 is a selective HDAC6 inhibitor, with an IC50 of 12 nM. SS-208 possesses anti-tumor activity in melanoma[1].

Name	SS-208

Description	SS-208 is a selective HDAC6 inhibitor, with an IC50 of 12 nM. SS-208 possesses anti-tumor activity in melanoma[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> HDAC Signaling Pathways >> Epigenetics >> HDAC
Target	HDAC6:12 nM (IC50) HDAC8:1.23 μM (IC50) HDAC1:1.39 μM (IC50) HDAC11:5.12 μM (IC50) HDAC5:6.91 μM (IC50) HDAC7:8.34 μM (IC50)
In Vivo	SS-208 (25 mg/kg, ip) significantly reduces the tumor growth in melanoma murine model[1]. Animal Model: C57BL/6 mice injected immunogenic murine SM1 melanoma cells subcutaneously[1]. Dosage: 25 mg/kg. Administration: IP on day 4, 7, 12, 15 and 18. Result: Significantly reduced the tumor growth.
References	[1]. Shen S, et al. Discovery of a New Isoxazole-3-hydroxamate-Based Histone Deacetylase 6 Inhibitor SS-208 with Antitumor Activity in Syngeneic Melanoma Mouse Models. J Med Chem. 2019 Sep 4.

Molecular Formula	C₁₃H₁₁Cl₂N₃O₄
Molecular Weight	344.15

DC Chemicals Limited
China
Product Name: SS-208
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

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