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2245942-72-5

2245942-72-5 structure
2245942-72-5 structure
  • Name: SS-208
  • Chemical Name: SS-208
  • CAS Number: 2245942-72-5
  • Molecular Formula: C13H11Cl2N3O4
  • Molecular Weight: 344.15
  • Catalog: Signaling Pathways Cell Cycle/DNA Damage HDAC
  • Create Date: 2019-10-09 11:02:29
  • Modify Date: 2024-01-20 18:37:20
  • SS-208 is a selective HDAC6 inhibitor, with an IC50 of 12 nM. SS-208 possesses anti-tumor activity in melanoma[1].
Name SS-208
Description SS-208 is a selective HDAC6 inhibitor, with an IC50 of 12 nM. SS-208 possesses anti-tumor activity in melanoma[1].
Related Catalog
Target

HDAC6:12 nM (IC50)

HDAC8:1.23 μM (IC50)

HDAC1:1.39 μM (IC50)

HDAC11:5.12 μM (IC50)

HDAC5:6.91 μM (IC50)

HDAC7:8.34 μM (IC50)

In Vivo SS-208 (25 mg/kg, ip) significantly reduces the tumor growth in melanoma murine model[1]. Animal Model: C57BL/6 mice injected immunogenic murine SM1 melanoma cells subcutaneously[1]. Dosage: 25 mg/kg. Administration: IP on day 4, 7, 12, 15 and 18. Result: Significantly reduced the tumor growth.
References

[1]. Shen S, et al. Discovery of a New Isoxazole-3-hydroxamate-Based Histone Deacetylase 6 Inhibitor SS-208 with Antitumor Activity in Syngeneic Melanoma Mouse Models. J Med Chem. 2019 Sep 4.
Molecular Formula C13H11Cl2N3O4
Molecular Weight 344.15

Chemsrc provides CAS#:2245942-72-5 MSDS, density, melting point, boiling point, structure, formula, molecular weight, synthetic route, etc.
title: CAS No. 2245942-72-5 | Chemsrc address: https://www.chemsrc.com/en/baike/1559235.html

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