SS-208

Names

[ CAS No. ]:
2245942-72-5

[ Name ]:
SS-208

Biological Activity

[Description]:

SS-208 is a selective HDAC6 inhibitor, with an IC50 of 12 nM. SS-208 possesses anti-tumor activity in melanoma[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> HDAC

Signaling Pathways >> Epigenetics >> HDAC

[Target]

HDAC6:12 nM (IC50)

HDAC8:1.23 μM (IC50)

HDAC1:1.39 μM (IC50)

HDAC11:5.12 μM (IC50)

HDAC5:6.91 μM (IC50)

HDAC7:8.34 μM (IC50)

[In Vivo]

SS-208 (25 mg/kg, ip) significantly reduces the tumor growth in melanoma murine model[1]. Animal Model: C57BL/6 mice injected immunogenic murine SM1 melanoma cells subcutaneously[1]. Dosage: 25 mg/kg. Administration: IP on day 4, 7, 12, 15 and 18. Result: Significantly reduced the tumor growth.

[References]

[1]. Shen S, et al. Discovery of a New Isoxazole-3-hydroxamate-Based Histone Deacetylase 6 Inhibitor SS-208 with Antitumor Activity in Syngeneic Melanoma Mouse Models. J Med Chem. 2019 Sep 4.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₃H₁₁Cl₂N₃O₄

[ Molecular Weight ]:
344.15

SS-208

Names

Biological Activity

Chemical & Physical Properties

Related Compounds