RIPK2-IN-1

Modify Date: 2025-08-26 19:50:37

RIPK2-IN-1 structure	Common Name	RIPK2-IN-1
	CAS Number	2245820-70-4	Molecular Weight	453.56
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₃H₂₇N₅O₃S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of RIPK2-IN-1

RIPK2-IN-1 (compound 18f) is a potent RIPK2 inhibitor with an IC50 of 51 nM. RIPK2-IN-1 inhibits ALK2 with an IC50 of 5 nM. RIPK2-IN-1 has an IC50 of 390 nM on RIPK2/NOD2 in cell assay[1].

Name	RIPK2-IN-1

Description	RIPK2-IN-1 (compound 18f) is a potent RIPK2 inhibitor with an IC50 of 51 nM. RIPK2-IN-1 inhibits ALK2 with an IC50 of 5 nM. RIPK2-IN-1 has an IC50 of 390 nM on RIPK2/NOD2 in cell assay[1].
Related Catalog	Signaling Pathways >> Apoptosis >> RIP kinase Signaling Pathways >> Protein Tyrosine Kinase/RTK >> ALK Research Areas >> Inflammation/Immunology
References	[1]. Chalada Suebsuwong, et al. Receptor-interacting protein kinase 2 (RIPK2) and nucleotide-binding oligomerization domain (NOD) cell signaling inhibitors based on a 3,5-diphenyl-2-aminopyridine scaffold. Eur J Med Chem. 2020 Aug 15;200:112417.

Molecular Formula	C₂₃H₂₇N₅O₃S
Molecular Weight	453.56
InChIKey	WTNLXMJMLHJDKF-UHFFFAOYSA-N
SMILES	COc1cc(NS(C)(=O)=O)cc(-c2cc(-c3ccc(N4CCNCC4)cc3)cnc2N)c1

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