RIPK2-IN-1

Names

[ Name ]:
RIPK2-IN-1

Biological Activity

[Description]:

RIPK2-IN-1 (compound 18f) is a potent RIPK2 inhibitor with an IC50 of 51 nM. RIPK2-IN-1 inhibits ALK2 with an IC50 of 5 nM. RIPK2-IN-1 has an IC50 of 390 nM on RIPK2/NOD2 in cell assay[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> RIP kinase

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> ALK

Research Areas >> Inflammation/Immunology

[References]

[1]. Chalada Suebsuwong, et al. Receptor-interacting protein kinase 2 (RIPK2) and nucleotide-binding oligomerization domain (NOD) cell signaling inhibitors based on a 3,5-diphenyl-2-aminopyridine scaffold. Eur J Med Chem. 2020 Aug 15;200:112417.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₃H₂₇N₅O₃S

[ Molecular Weight ]:
453.56

Related Compounds

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