BTRX-335140(CYM-53093

Modify Date: 2025-09-10 18:01:12

BTRX-335140(CYM-53093 Structure
BTRX-335140(CYM-53093 structure
 Common Name BTRX-335140(CYM-53093
CAS Number 2244614-14-8 Molecular Weight 453.55
Density N/A Boiling Point N/A
Molecular Formula C25H32FN5O2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of BTRX-335140(CYM-53093


BTRX-335140 (CYM-53093) is a potent and selective, orally active κ opioid receptor (KOR) antagonist, has antagonist activity for κOR, μOR and δOR with IC50 values of 0.8 nM, 110 nM, and 6500 nM, respectively.BTRX-335140 endows with favorable in vitro ADMET and in vivo pharmacokinetic profiles and medication-like duration of action in rats. BTRX-335140 can distribute well into the CNS. ADMET (absorption, distribution, metabolism, excretion, and toxicity) [1].

 Names

Name BTRX-335140

 BTRX-335140(CYM-53093 Biological Activity

Description BTRX-335140 (CYM-53093) is a potent and selective, orally active κ opioid receptor (KOR) antagonist, has antagonist activity for κOR, μOR and δOR with IC50 values of 0.8 nM, 110 nM, and 6500 nM, respectively.BTRX-335140 endows with favorable in vitro ADMET and in vivo pharmacokinetic profiles and medication-like duration of action in rats. BTRX-335140 can distribute well into the CNS. ADMET (absorption, distribution, metabolism, excretion, and toxicity) [1].
Related Catalog
Target

IC50: 0.8 nM (κOR); 110 nM (μOR); 6500 nM (δOR)[1]

References

[1]. Guerrero M, et al. Design and Synthesis of a Novel and Selective Kappa Opioid Receptor (KOR) Antagonist (BTRX-335140). J Med Chem. 2019 Feb 28;62(4):1761-1780.

 Chemical & Physical Properties

Molecular Formula C25H32FN5O2
Molecular Weight 453.55
InChIKey CQOJHAJWCDJEAT-UHFFFAOYSA-N
SMILES CCc1cc(F)c2nc(N3CCC(NC4CCOCC4)CC3)c(-c3nc(C)no3)c(C)c2c1
Storage condition 2-8°C
The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.
Top Suppliers:I want be here

Get all suppliers and price by the below link:

BTRX-335140(CYM-53093 suppliers

BTRX-335140(CYM-53093 price

Related Compounds: More...
Sulfamide, o-cym-4-yl- (7CI,8CI)
6386-62-5
CYM2503
1308833-36-4
[Ru(OCOH)2(p-cym)PPh3]
1151886-68-8
Montelukast Methyl Ketone
937275-23-5
Terlakiren
119625-78-4
[Ru(η6-p-cymene)Cl2(DMSO)]
115543-07-2
(1R,2S)-1-Phenyl-2-(1-pyrrolidinyl)-1-propanol hydrochloride (1:1 )
210558-66-0
CYM5442
1094042-01-9
promecarb
2631-37-0
4-isopropyl-6-(2-oxo-2-(piperidin-1-yl)ethyl)-1-(o-tolyl)-1H-pyrazolo[3,4-d]pyridazin-7(6H)-one
946379-31-3
1-{1-[3-(3,5-dimethylphenoxy)propyl]-1H-benzimidazol-2-yl}propan-1-ol
898651-39-3
(E)-1-(1-(3-(2-methoxy-4-(prop-1-en-1-yl)phenoxy)propyl)-1H-benzo[d]imidazol-2-yl)propan-1-ol
898651-44-0
4-isopropyl-6-(2-oxo-2-(4-phenylpiperazin-1-yl)ethyl)-1-(o-tolyl)-1H-pyrazolo[3,4-d]pyridazin-7(6H)-one
955839-87-9
6-(2-(3,4-dihydroquinolin-1(2H)-yl)-2-oxoethyl)-4-isopropyl-1-(o-tolyl)-1H-pyrazolo[3,4-d]pyridazin-7(6H)-one
946204-41-7
6-(2-(indolin-1-yl)-2-oxoethyl)-4-isopropyl-1-(o-tolyl)-1H-pyrazolo[3,4-d]pyridazin-7(6H)-one
946253-67-4
2-(4-isopropyl-7-oxo-1-(o-tolyl)-1H-pyrazolo[3,4-d]pyridazin-6(7H)-yl)-N-(m-tolyl)acetamide
946332-43-0
N-(3-fluorophenyl)-2-(4-isopropyl-7-oxo-1-(o-tolyl)-1H-pyrazolo[3,4-d]pyridazin-6(7H)-yl)acetamide
946379-34-6
N-(4-fluorophenyl)-2-(4-isopropyl-7-oxo-1-(o-tolyl)-1H-pyrazolo[3,4-d]pyridazin-6(7H)-yl)acetamide
955848-63-2
2-(4-isopropyl-7-oxo-1-(o-tolyl)-1H-pyrazolo[3,4-d]pyridazin-6(7H)-yl)-N-(4-methoxyphenyl)acetamide
946204-44-0
Chemsrc provides BTRX-335140(CYM-53093(CAS#:2244614-14-8) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of BTRX-335140(CYM-53093 are included as well.>> amp version: BTRX-335140(CYM-53093

Home | MSDS/SDS Database Search | Journals | Product Classification | Biologically Active Compounds | Selling Leads | About Us | Disclaimer

Copyright © 2024 ChemSrc All Rights Reserved