2244614-14-8

2244614-14-8 structure

Name: BTRX-335140(CYM-53093
Chemical Name: BTRX-335140
CAS Number: 2244614-14-8
Molecular Formula: C₂₅H₃₂FN₅O₂
Molecular Weight: 453.55
Catalog: Signaling Pathways GPCR/G Protein Opioid Receptor
Create Date: 2019-10-08 11:16:52
Modify Date: 2024-01-10 12:39:55
BTRX-335140 (CYM-53093) is a potent and selective, orally active κ opioid receptor (KOR) antagonist, has antagonist activity for κOR, μOR and δOR with IC50 values of 0.8 nM, 110 nM, and 6500 nM, respectively.BTRX-335140 endows with favorable in vitro ADMET and in vivo pharmacokinetic profiles and medication-like duration of action in rats. BTRX-335140 can distribute well into the CNS. ADMET (absorption, distribution, metabolism, excretion, and toxicity) [1].

Name	BTRX-335140

Description	BTRX-335140 (CYM-53093) is a potent and selective, orally active κ opioid receptor (KOR) antagonist, has antagonist activity for κOR, μOR and δOR with IC50 values of 0.8 nM, 110 nM, and 6500 nM, respectively.BTRX-335140 endows with favorable in vitro ADMET and in vivo pharmacokinetic profiles and medication-like duration of action in rats. BTRX-335140 can distribute well into the CNS. ADMET (absorption, distribution, metabolism, excretion, and toxicity) [1].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Opioid Receptor Research Areas >> Metabolic Disease Signaling Pathways >> Neuronal Signaling >> Opioid Receptor
Target	IC50: 0.8 nM (κOR); 110 nM (μOR); 6500 nM (δOR)[1]
References	[1]. Guerrero M, et al. Design and Synthesis of a Novel and Selective Kappa Opioid Receptor (KOR) Antagonist (BTRX-335140). J Med Chem. 2019 Feb 28;62(4):1761-1780.