Nampt activator-2
Modify Date: 2025-09-05 10:26:09
Nampt activator-2 structure
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Common Name | Nampt activator-2 | ||
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| CAS Number | 2237268-90-3 | Molecular Weight | 390.84 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C17H15ClN4O3S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Nampt activator-2Nampt activator-2 (compound 34) is a potent NAMPT activator, with EC50 of 0.023 μM. Nampt activator-2 shows moderate activity against CYP2C9 (0.060 μM), 2D6 (0.41 μM) and 2C19 (0.59 μM)[1]. |
| Name | Nampt activator-2 |
|---|
| Description | Nampt activator-2 (compound 34) is a potent NAMPT activator, with EC50 of 0.023 μM. Nampt activator-2 shows moderate activity against CYP2C9 (0.060 μM), 2D6 (0.41 μM) and 2C19 (0.59 μM)[1]. |
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| Related Catalog | |
| In Vitro | Nampt activator-2 (compound 34) (10 μM, 4 h) 导致 A549 肺上皮细胞中 NMN 和 NAD 显着增加[1]。 |
| In Vivo | Nampt activator-2 (compound 34) (1mg/kg 静脉注射和10mg /kg 口服，一次) 表现出低血浆清除率、良好的暴露和出色的口服生物利用度 (%F = 80)[1]。 Animal Model: Mouse[1] Dosage: 1 mg/kg iv and 10 mg/kg po Administration: IV, PO; once (Pharmacokinetic Analysis) Result: Pharmacokinetic Parameters of Nampt activator-2 in mouse[1]. IV (1 mg/kg) PO (10 mg/kg) Cmax (ng/mL) 9550 AUC0-24 (ng/mL∗h) 54463 t1/2 (h) 3.2 CL (mL/min/kg) 3 Vd (L/kg) 0.61 F (%) 80 |
| References |
| Molecular Formula | C17H15ClN4O3S |
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| Molecular Weight | 390.84 |