1501618-04-7

1501618-04-7 structure

Name: EIF2α activator 2
Chemical Name: EIF2α activator 2
CAS Number: 1501618-04-7
Molecular Formula: C₂₁H₂₀F₆N₂O₂
Molecular Weight: 446.39
Catalog: Signaling Pathways Cell Cycle/DNA Damage Eukaryotic Initiation Factor (eIF)
Create Date: 2022-08-05 20:19:48
Modify Date: 2025-08-25 14:38:58
EIF2α activator 2 (Compound 1) is an activator of eukaryotic initiation factor 2 alpha (eIF2α) phosphorylation. EIF2α activator 2 exhibits high potency in SRB cell proliferation assays (IC50=0.46 μM). EIF2α activator 2 exhibits antiproliferative activity againist K562 and PBMC cells with IC50s of 4.79 and 10.52 μM, respectively[1].

Name	EIF2α activator 2

Description	EIF2α activator 2 (Compound 1) is an activator of eukaryotic initiation factor 2 alpha (eIF2α) phosphorylation. EIF2α activator 2 exhibits high potency in SRB cell proliferation assays (IC50=0.46 μM). EIF2α activator 2 exhibits antiproliferative activity againist K562 and PBMC cells with IC50s of 4.79 and 10.52 μM, respectively[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Eukaryotic Initiation Factor (eIF)
References	[1]. Jinsook Kwak, et al. A bioisosteric approach to the discovery of novel N-aryl-N'-[4-(aryloxy)cyclohexyl]squaramide-based activators of eukaryotic initiation factor 2 alpha (eIF2α) phosphorylation. Eur J Med Chem. 2022 May 29;239:114501.

Molecular Formula	C₂₁H₂₀F₆N₂O₂
Molecular Weight	446.39