Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Nampt activator-2
Price: Check
Purity: 98.46%
Stocking Period: 10 Day
Contact: Yang
Email: sales@echemcloud.com

2237268-90-3

2237268-90-3 structure

2237268-90-3 structure

Name: Nampt activator-2
Chemical Name: Nampt activator-2
CAS Number: 2237268-90-3
Molecular Formula: C₁₇H₁₅ClN₄O₃S
Molecular Weight: 390.84
Catalog: Signaling Pathways Metabolic Enzyme/Protease Nampt
Create Date: 2023-04-04 09:18:23
Modify Date: 2025-09-05 10:26:09
Nampt activator-2 (compound 34) is a potent NAMPT activator, with EC50 of 0.023 μM. Nampt activator-2 shows moderate activity against CYP2C9 (0.060 μM), 2D6 (0.41 μM) and 2C19 (0.59 μM)[1].

Name	Nampt activator-2

Description	Nampt activator-2 (compound 34) is a potent NAMPT activator, with EC50 of 0.023 μM. Nampt activator-2 shows moderate activity against CYP2C9 (0.060 μM), 2D6 (0.41 μM) and 2C19 (0.59 μM)[1].
Related Catalog	Research Areas >> Neurological Disease Signaling Pathways >> Metabolic Enzyme/Protease >> Nampt
In Vitro	Nampt activator-2 (compound 34) (10 μM, 4 h) 导致 A549 肺上皮细胞中 NMN 和 NAD 显着增加[1]。
In Vivo	Nampt activator-2 (compound 34) (1mg/kg 静脉注射和10mg /kg 口服，一次) 表现出低血浆清除率、良好的暴露和出色的口服生物利用度 (%F = 80)[1]。 Animal Model: Mouse[1] Dosage: 1 mg/kg iv and 10 mg/kg po Administration: IV, PO; once (Pharmacokinetic Analysis) Result: Pharmacokinetic Parameters of Nampt activator-2 in mouse[1]. IV (1 mg/kg) PO (10 mg/kg) Cmax (ng/mL) 9550 AUC0-24 (ng/mL∗h) 54463 t1/2 (h) 3.2 CL (mL/min/kg) 3 Vd (L/kg) 0.61 F (%) 80
References	[1]. Pinkerton AB, et al. Optimization of a urea-containing series of nicotinamide phosphoribosyltransferase (NAMPT) activators. Bioorg Med Chem Lett. 2021 Jun 1;41:128007.

Molecular Formula	C₁₇H₁₅ClN₄O₃S
Molecular Weight	390.84

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.