Keap1-Nrf2-IN-1

Modify Date: 2024-01-11 16:34:14

Keap1-Nrf2-IN-1 structure	Common Name	Keap1-Nrf2-IN-1
	CAS Number	2232112-72-8	Molecular Weight	484.52
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₄H₂₄N₂O₇S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Keap1-Nrf2-IN-1

Keap1–Nrf2 IN-1 (compound35) is a Kelch-like ECH-associated protein 1-nuclear factor erythroid 2-related factor 2 (Keap1-Nrf2) protein-protein interaction inhibitor, and with an IC50 of 43 nM for Keap1 protein. Keap1–Nrf2 IN-1 (compound35) activates Nrf2-regulated cytoprotective response and antagonizes acetaminophen-induced liver injury both in cellular and in vivo models[1].

Name	Keap1–Nrf2-IN-1

Description	Keap1–Nrf2 IN-1 (compound35) is a Kelch-like ECH-associated protein 1-nuclear factor erythroid 2-related factor 2 (Keap1-Nrf2) protein-protein interaction inhibitor, and with an IC50 of 43 nM for Keap1 protein. Keap1–Nrf2 IN-1 (compound35) activates Nrf2-regulated cytoprotective response and antagonizes acetaminophen-induced liver injury both in cellular and in vivo models[1].
Related Catalog	Signaling Pathways >> NF-κB >> Keap1-Nrf2 Research Areas >> Inflammation/Immunology Research Areas >> Metabolic Disease
Target	IC50: 43 nM (Keap1 protein)[1]
References	[1]. Lu MC, et al. Discovery of a Potent Kelch-Like ECH-Associated Protein 1-Nuclear Factor Erythroid 2-Related Factor 2 (Keap1-Nrf2) Protein-Protein Interaction Inhibitor with Natural Proline Structure as a Cytoprotective Agent against Acetaminophen-Induced Hepatotoxicity. J Med Chem. 2019 Jul 25;62(14):6796-6813.

Molecular Formula	C₂₄H₂₄N₂O₇S
Molecular Weight	484.52

DC Chemicals Limited
China
Product Name: Keap1-Nrf2-IN-1
Price: $Inquiry/250mg $Inquiry/100mg $Inquiry/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

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