2250082-04-1

2250082-04-1 structure

2250082-04-1 structure

Name: Keap1-Nrf2-IN-12
Chemical Name: Keap1-Nrf2-IN-12
CAS Number: 2250082-04-1
Molecular Formula: C₂₆H₂₈N₂O₁₀S₂
Molecular Weight: 592.64
Catalog: Signaling Pathways NF-κB Keap1-Nrf2
Create Date: 2022-09-13 18:40:05
Modify Date: 2024-01-12 16:00:02
Keap1-Nrf2-IN-12 is a potent Keap1-Nrf2 inhibitor with an IC50 value of 2.30 µM. Keap1-Nrf2-IN-12 shows metabolic stability in human liver microsomes[1].

Name	Keap1-Nrf2-IN-12

Description	Keap1-Nrf2-IN-12 is a potent Keap1-Nrf2 inhibitor with an IC50 value of 2.30 µM. Keap1-Nrf2-IN-12 shows metabolic stability in human liver microsomes[1].
Related Catalog	Signaling Pathways >> NF-κB >> Keap1-Nrf2 Research Areas >> Inflammation/Immunology
Target	IC50: 2.30 µM (Keap1-Nrf2)[1].
In Vitro	Keap1-Nrf2-IN-12 (compound 9a) shows metabolic stability in human liver microsomes with slight changes (97.7% remained) after 90 min of incubation[1].
References	[1]. Abed DA, et al. Discovery of disubstituted xylylene derivatives as small molecule direct inhibitors of Keap1-Nrf2 protein-protein interaction. Bioorg Med Chem. 2020 Mar 15;28(6):115343.

Molecular Formula	C₂₆H₂₈N₂O₁₀S₂
Molecular Weight	592.64