2232112-72-8

2232112-72-8 structure

Name: Keap1-Nrf2-IN-1
Chemical Name: Keap1–Nrf2-IN-1
CAS Number: 2232112-72-8
Molecular Formula: C₂₄H₂₄N₂O₇S
Molecular Weight: 484.52
Catalog: Signaling Pathways NF-κB Keap1-Nrf2
Create Date: 2019-09-09 19:53:51
Modify Date: 2024-01-11 16:34:14
Keap1–Nrf2 IN-1 (compound35) is a Kelch-like ECH-associated protein 1-nuclear factor erythroid 2-related factor 2 (Keap1-Nrf2) protein-protein interaction inhibitor, and with an IC50 of 43 nM for Keap1 protein. Keap1–Nrf2 IN-1 (compound35) activates Nrf2-regulated cytoprotective response and antagonizes acetaminophen-induced liver injury both in cellular and in vivo models[1].

Name	Keap1–Nrf2-IN-1

Description	Keap1–Nrf2 IN-1 (compound35) is a Kelch-like ECH-associated protein 1-nuclear factor erythroid 2-related factor 2 (Keap1-Nrf2) protein-protein interaction inhibitor, and with an IC50 of 43 nM for Keap1 protein. Keap1–Nrf2 IN-1 (compound35) activates Nrf2-regulated cytoprotective response and antagonizes acetaminophen-induced liver injury both in cellular and in vivo models[1].
Related Catalog	Signaling Pathways >> NF-κB >> Keap1-Nrf2 Research Areas >> Inflammation/Immunology Research Areas >> Metabolic Disease
Target	IC50: 43 nM (Keap1 protein)[1]
References	[1]. Lu MC, et al. Discovery of a Potent Kelch-Like ECH-Associated Protein 1-Nuclear Factor Erythroid 2-Related Factor 2 (Keap1-Nrf2) Protein-Protein Interaction Inhibitor with Natural Proline Structure as a Cytoprotective Agent against Acetaminophen-Induced Hepatotoxicity. J Med Chem. 2019 Jul 25;62(14):6796-6813.

Molecular Formula	C₂₄H₂₄N₂O₇S
Molecular Weight	484.52