3′-O-Demethyl-4′-N-demethyl-4′-N-acetyl-4′-epi-staurosporine

Modify Date: 2025-08-26 14:29:08

3′-O-Demethyl-4′-N-demethyl-4′-N-acetyl-4′-epi-staurosporine structure	Common Name	3′-O-Demethyl-4′-N-demethyl-4′-N-acetyl-4′-epi-staurosporine
	CAS Number	2226941-29-1	Molecular Weight	480.51
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₈H₂₄N₄O₄	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of 3′-O-Demethyl-4′-N-demethyl-4′-N-acetyl-4′-epi-staurosporine

3′-O-Demethyl-4′-N-demethyl-4′-N-acetyl-4′-epi-staurosporine (Compound 7) is an inhibitor of protein kinases, with IC50s of 0.092, 0.26, 0.77 μM for PKC-α, ROCK, ASK1. 3′-O-Demethyl-4′-N-demethyl-4′-N-acetyl-4′-epi-staurosporine shows potent cytotoxicity against PC-3 cancer cells with an IC50 value of 0.16 μM[1].

Name	3′-O-Demethyl-4′-N-demethyl-4′-N-acetyl-4′-epi-staurosporine

Description	3′-O-Demethyl-4′-N-demethyl-4′-N-acetyl-4′-epi-staurosporine (Compound 7) is an inhibitor of protein kinases, with IC50s of 0.092, 0.26, 0.77 μM for PKC-α, ROCK, ASK1. 3′-O-Demethyl-4′-N-demethyl-4′-N-acetyl-4′-epi-staurosporine shows potent cytotoxicity against PC-3 cancer cells with an IC50 value of 0.16 μM[1].
Related Catalog	Signaling Pathways >> Epigenetics >> PKC Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> ROCK Signaling Pathways >> MAPK/ERK Pathway >> p38 MAPK Signaling Pathways >> TGF-beta/Smad >> PKC Signaling Pathways >> Stem Cell/Wnt >> ROCK Signaling Pathways >> TGF-beta/Smad >> ROCK
References	[1]. Wang JN, et al. Bioactive Indolocarbazoles from the Marine-Derived Streptomyces sp. DT-A61. J Nat Prod. 2018 Apr 27;81(4):949-956.

Molecular Formula	C₂₈H₂₄N₄O₄
Molecular Weight	480.51

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3′-O-Demethyl-4′-N-demethyl-4′-N-acetyl-4′-epi-staurosporine

Use of 3′-O-Demethyl-4′-N-demethyl-4′-N-acetyl-4′-epi-staurosporine

Names

Biological Activity

Chemical & Physical Properties

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.