3′-O-Demethyl-4′-N-demethyl-4′-N-acetyl-4′-epi-staurosporine

Names

[ CAS No. ]:
2226941-29-1

[ Name ]:
3′-O-Demethyl-4′-N-demethyl-4′-N-acetyl-4′-epi-staurosporine

Biological Activity

[Description]:

3′-O-Demethyl-4′-N-demethyl-4′-N-acetyl-4′-epi-staurosporine (Compound 7) is an inhibitor of protein kinases, with IC50s of 0.092, 0.26, 0.77 μM for PKC-α, ROCK, ASK1. 3′-O-Demethyl-4′-N-demethyl-4′-N-acetyl-4′-epi-staurosporine shows potent cytotoxicity against PC-3 cancer cells with an IC50 value of 0.16 μM[1].

[Related Catalog]:

Signaling Pathways >> Epigenetics >> PKC
Research Areas >> Cancer
Signaling Pathways >> Cell Cycle/DNA Damage >> ROCK
Signaling Pathways >> MAPK/ERK Pathway >> p38 MAPK
Signaling Pathways >> TGF-beta/Smad >> PKC
Signaling Pathways >> Stem Cell/Wnt >> ROCK
Signaling Pathways >> TGF-beta/Smad >> ROCK

[References]

[1]. Wang JN, et al. Bioactive Indolocarbazoles from the Marine-Derived Streptomyces sp. DT-A61. J Nat Prod. 2018 Apr 27;81(4):949-956.  

Chemical & Physical Properties

[ Molecular Formula ]:
C28H24N4O4

[ Molecular Weight ]:
480.51

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.