Spectinomycin dihydrochloride pentahydrate structure
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Common Name | Spectinomycin dihydrochloride pentahydrate | ||
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CAS Number | 22189-32-8 | Molecular Weight | 495.348 | |
Density | N/A | Boiling Point | 583.1ºC at 760 mmHg | |
Molecular Formula | C14H36Cl2N2O12 | Melting Point | 205-207° (dec) | |
MSDS | Chinese USA | Flash Point | 306.4ºC |
Use of Spectinomycin dihydrochloride pentahydrateSpectinomycin dihydrochloride pentahydrate is a broad-spectrum aminocyclitol antibiotic that inhibits the growth of a variety of gram-positive and gram-negative organisms. |
Name | spectinomycin hydrochloride hydrate |
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Synonym | More Synonyms |
Description | Spectinomycin dihydrochloride pentahydrate is a broad-spectrum aminocyclitol antibiotic that inhibits the growth of a variety of gram-positive and gram-negative organisms. |
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Related Catalog | |
In Vitro | Spectinomycin selectively inhibits protein synthesis in cells and in extracts of Escherichia coli. When added to an exponentially growing culture, spectinomycin (50 μg/mL) rapidly and reversibly inhibits growth of Escherichia coli. Amino acid incorporation is slowed immediately but RNA synthesis continued. In extracts of Escherichia coli B, spectinomycin inhibits polypeptide synthesis directed either by endogenous messenger RNA or by MS-2 bacteriophage RNA. Maximum inhibition (70 to 80%) is achieved at 1 μg/mL (3 μM). [1]. Spectinomycin blocks the translocation of peptidyl-tRNAs from the A-site to the P-site by inhibiting the binding of elongation factor G to the ribosome. Spectinomycin interacts specifically with the residues G1064 and 01192 in 16S rRNA and potentially change this molecule into an inactive conformation[2]. Spectinomycin acts as a mixed noncompetitive inhibitor for the td intron RNA with a Ki of 7.2 mM. The splicing inhibition by spectinomycin is dependent on pH changes and Mg2+ concentration, indicating electrostatic interactions with the intron RNA[3]. |
In Vivo | Renal excretion is a major elimination pathway for spectinomycin. Following IV administration, approximately 55% of the drug is excreted into the urine in unchanged form. After IV administration of 10 mg/kg spectinomycin shows a peak plasma concentration of 37.8 μg/mL and a systemic exposure (area-under the curve AUC0-∞) of 15.7 μg/mL. Following single dose intramuscular administration, the overall elimination half-life of spectinomycin is 1.2 h in cattle, 1.0 h in sheep, 1.0 h in pigs, 1.65 h in chicken and 1.85 h in humans[4]. |
Animal Admin | Rats: Spectinomycin (10 mg/kg) is administered intravenously to rats. Serial blood samples (approx. 250 μL) are collected pre-dose, and at 0.25, 0.5, 0.75, 1.0, 1.5, 2.0, 4.0, 6.0, 8.0, 12.0, 24.0, 36.0 and 48.0 h post-dose. Plasma is separated immediately by centrifugation (10,000g for 5 min at 4°C) and stored at −80°C until analysis. Urine samples are collected at an interval of 0-6, 6-12, 12-24, 24-36 and 36-48 h post-dose and stored at −80°C until analysis[4]. |
References |
Boiling Point | 583.1ºC at 760 mmHg |
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Melting Point | 205-207° (dec) |
Molecular Formula | C14H36Cl2N2O12 |
Molecular Weight | 495.348 |
Flash Point | 306.4ºC |
Exact Mass | 494.164520 |
PSA | 175.66000 |
Vapour Pressure | 5.05E-16mmHg at 25°C |
Storage condition | 2~8°C |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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4H-Pyrano[2,3-b][1,4]benzodioxin-4-one, decahydro-4a,7,9-trihydroxy-2-methyl-6,8-bis(methylamino)-, (2S,6R,7R,8S,9S)-, hydrochloride, hydrate (1:2:5) |
4H-Pyrano[2,3-b][1,4]benzodioxin-4-one, decahydro-4a,7,9-trihydroxy-2-methyl-6,8-bis(methylamino)-, (2R,4aR,5aR,6S,7S,8R,9S,9aR,10aS)-, hydrochloride, hydrate (1:2:5) |
MFCD00150886 |
spectogard |
EINECS 244-554-3 |
(2R,4aR,5aR,6S,7S,8R,9S,9aR,10aS)-4a,7,9-Trihydroxy-2-methyl-6,8-bis(methylamino)decahydro-4H-pyrano[2,3-b][1,4]benzodioxin-4-one dihydrochloride pentahydrate |
Spectinomycin pentahydrate dihydrochloride |
ACTINOSPECTACIN DIHYDROCHLORIDE |
Spectinomycin HCL USP/BP |
Spectinomycin dihydrochloride pentahydrate |
SPECTINOMYCIN 2HCL |
(2S,6R,7R,8S,9S)-4a,7,9-Trihydroxy-2-methyl-6,8-bis(methylamino)decahydro-4H-pyrano[2,3-b][1,4]benzodioxin-4-one dihydrochloride pentahydrate |
Trobicin (tn) |
SPECTINOMYCIN HCL |
Spectinomycin hydrochloride |
SpectinomycinHydrochloride |