Fmoc-Ala-Glu-Asn-Lys-NH2

Modify Date: 2025-11-11 18:47:31

Fmoc-Ala-Glu-Asn-Lys-NH2 Structure
Fmoc-Ala-Glu-Asn-Lys-NH2 structure
 Common Name Fmoc-Ala-Glu-Asn-Lys-NH2
CAS Number 220701-06-4 Molecular Weight 681.74
Density N/A Boiling Point N/A
Molecular Formula C33H43N7O9 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Fmoc-Ala-Glu-Asn-Lys-NH2


Fmoc-Ala-Glu-Asn-Lys-NH2 is a selective asparagine endopeptidase (AEP) inhibitor peptide and suppresses amyloid precursor protein (APP) cleavage. AEP, a pH-controlled cysteine proteinase, is activated during ageing and mediates APP proteolytic processing[1].

 Names

Name Fmoc-Ala-Glu-Asn-Lys-NH2

 Fmoc-Ala-Glu-Asn-Lys-NH2 Biological Activity

Description Fmoc-Ala-Glu-Asn-Lys-NH2 is a selective asparagine endopeptidase (AEP) inhibitor peptide and suppresses amyloid precursor protein (APP) cleavage. AEP, a pH-controlled cysteine proteinase, is activated during ageing and mediates APP proteolytic processing[1].
Related Catalog
In Vitro Fmoc-Ala-Glu-Asn-Lys-NH2 antagonizes APP processing by AEP, whereas other small molecular inhibitors and inactive peptide AEQK were without effect[1].
References

[1]. Zhang Z, et al. Delta-secretase cleaves amyloid precursor protein and regulates the pathogenesis in Alzheimer's disease. Nat Commun. 2015;6:8762. Published 2015 Nov 9.

 Chemical & Physical Properties

Molecular Formula C33H43N7O9
Molecular Weight 681.74
InChIKey SAWVPDQXSCHRKB-UZTPZCRESA-N
SMILES CC(NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)NC(CCC(=O)O)C(=O)NC(CC(N)=O)C(=O)NC(CCCCN)C(N)=O
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Chemsrc provides Fmoc-Ala-Glu-Asn-Lys-NH2(CAS#:220701-06-4) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of Fmoc-Ala-Glu-Asn-Lys-NH2 are included as well.>> amp version: Fmoc-Ala-Glu-Asn-Lys-NH2

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