Fmoc-Ala-Glu-Asn-Lys-NH2

Names

[ CAS No. ]:
220701-06-4

[ Name ]:
Fmoc-Ala-Glu-Asn-Lys-NH2

Biological Activity

[Description]:

Fmoc-Ala-Glu-Asn-Lys-NH2 is a selective asparagine endopeptidase (AEP) inhibitor peptide and suppresses amyloid precursor protein (APP) cleavage. AEP, a pH-controlled cysteine proteinase, is activated during ageing and mediates APP proteolytic processing[1].

[Related Catalog]:

Research Areas >> Neurological Disease

[In Vitro]

Fmoc-Ala-Glu-Asn-Lys-NH2 antagonizes APP processing by AEP, whereas other small molecular inhibitors and inactive peptide AEQK were without effect[1].

[References]

[1]. Zhang Z, et al. Delta-secretase cleaves amyloid precursor protein and regulates the pathogenesis in Alzheimer's disease. Nat Commun. 2015;6:8762. Published 2015 Nov 9.

Chemical & Physical Properties

[ Molecular Formula ]:
C₃₃H₄₃N₇O₉

[ Molecular Weight ]:
681.74

Fmoc-Ala-Glu-Asn-Lys-NH2

Names

Biological Activity

Chemical & Physical Properties

Related Compounds