220701-06-4

220701-06-4 structure

Name: Fmoc-Ala-Glu-Asn-Lys-NH2
Chemical Name: Fmoc-Ala-Glu-Asn-Lys-NH2
CAS Number: 220701-06-4
Molecular Formula: C₃₃H₄₃N₇O₉
Molecular Weight: 681.74
Catalog: Research Areas Neurological Disease
Create Date: 2021-09-11 13:20:00
Modify Date: 2024-01-12 17:28:40
Fmoc-Ala-Glu-Asn-Lys-NH2 is a selective asparagine endopeptidase (AEP) inhibitor peptide and suppresses amyloid precursor protein (APP) cleavage. AEP, a pH-controlled cysteine proteinase, is activated during ageing and mediates APP proteolytic processing[1].

Name	Fmoc-Ala-Glu-Asn-Lys-NH2

Description	Fmoc-Ala-Glu-Asn-Lys-NH2 is a selective asparagine endopeptidase (AEP) inhibitor peptide and suppresses amyloid precursor protein (APP) cleavage. AEP, a pH-controlled cysteine proteinase, is activated during ageing and mediates APP proteolytic processing[1].
Related Catalog	Research Areas >> Neurological Disease
In Vitro	Fmoc-Ala-Glu-Asn-Lys-NH2 antagonizes APP processing by AEP, whereas other small molecular inhibitors and inactive peptide AEQK were without effect[1].
References	[1]. Zhang Z, et al. Delta-secretase cleaves amyloid precursor protein and regulates the pathogenesis in Alzheimer's disease. Nat Commun. 2015;6:8762. Published 2015 Nov 9.

Molecular Formula	C₃₃H₄₃N₇O₉
Molecular Weight	681.74