(+)-Coclaurine

Modify Date: 2024-01-06 21:34:54

(+)-Coclaurine Structure
(+)-Coclaurine structure
Common Name (+)-Coclaurine
CAS Number 2196-60-3 Molecular Weight 285.33800
Density 1.232g/cm3 Boiling Point 496.9ºC at 760 mmHg
Molecular Formula C17H19NO3 Melting Point 222-224 °C
MSDS N/A Flash Point 254.3ºC

 Use of (+)-Coclaurine


(+)-Coclaurine ((+)-(R)-Coclaurine), benzyltetrahydroisoquinoline alkaloid isolated from a variety of plant sources. (+)-Coclaurine has anti-aging activity[1][2].

 Names

Name (R)-coclaurine
Synonym More Synonyms

 (+)-Coclaurine Biological Activity

Description (+)-Coclaurine ((+)-(R)-Coclaurine), benzyltetrahydroisoquinoline alkaloid isolated from a variety of plant sources. (+)-Coclaurine has anti-aging activity[1][2].
Related Catalog
In Vivo An intracerebroventricular injection of (+)-Coclaurine (d-Coclaurine; 50 μg) produces a slight increase in 3,4-dihydroxyphenylacetic acid level and a significant increase in homovanillic acid level in the mouse striatum. (+)-Coclaurine blocks postsynaptic but not presynaptic dopamine receptors in the mouse striatum[2].
References

[1]. Siva S Panda, et al. Protective effects of Aporosa octandra bark extract against D-galactose induced cognitive impairment and oxidative stress in mice. Heliyon. 2018 Nov 30;4(11):e00951.

[2]. H Watanabe, et al. Effects of d-coclaurine and d-reticuline, benzyltetrahydroisoquinoline alkaloids, on levels of 3,4-dihydroxyphenylacetic acid and homovanillic acid in the mouse striatum. J Pharmacobiodyn. 1983 Oct;6(10):793-6.

 Chemical & Physical Properties

Density 1.232g/cm3
Boiling Point 496.9ºC at 760 mmHg
Melting Point 222-224 °C
Molecular Formula C17H19NO3
Molecular Weight 285.33800
Flash Point 254.3ºC
Exact Mass 285.13600
PSA 61.72000
LogP 2.86470
Vapour Pressure 1.69E-10mmHg at 25°C
Index of Refraction 1.62

 Safety Information

HS Code 2933499090

 Customs

HS Code 2933499090
Summary 2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Synonyms

R-Coclaurin
(+)-1R-Cocluaurine
(+)-Coclaurine
(1R)-1-[(4-hydroxyphenyl)methyl]-6-methoxy-1,2,3,4-tetrahydroisoquinolin-7-ol
(+)-1(R)-Coclaurine
d-Coclaurine
(R)-Coclaurine