(+)-Coclaurine

Names

[ Name ]:
(+)-Coclaurine

[Synonym ]:
R-Coclaurin
(+)-1R-Cocluaurine
(+)-Coclaurine
(1R)-1-[(4-hydroxyphenyl)methyl]-6-methoxy-1,2,3,4-tetrahydroisoquinolin-7-ol
(+)-1(R)-Coclaurine
d-Coclaurine
(R)-Coclaurine

Biological Activity

[Description]:

(+)-Coclaurine ((+)-(R)-Coclaurine), benzyltetrahydroisoquinoline alkaloid isolated from a variety of plant sources. (+)-Coclaurine has anti-aging activity[1][2].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Neurological Disease

[In Vivo]

An intracerebroventricular injection of (+)-Coclaurine (d-Coclaurine; 50 μg) produces a slight increase in 3,4-dihydroxyphenylacetic acid level and a significant increase in homovanillic acid level in the mouse striatum. (+)-Coclaurine blocks postsynaptic but not presynaptic dopamine receptors in the mouse striatum[2].

[References]

[1]. Siva S Panda, et al. Protective effects of Aporosa octandra bark extract against D-galactose induced cognitive impairment and oxidative stress in mice. Heliyon. 2018 Nov 30;4(11):e00951.

[2]. H Watanabe, et al. Effects of d-coclaurine and d-reticuline, benzyltetrahydroisoquinoline alkaloids, on levels of 3,4-dihydroxyphenylacetic acid and homovanillic acid in the mouse striatum. J Pharmacobiodyn. 1983 Oct;6(10):793-6.

Chemical & Physical Properties

[ Density]:
1.232g/cm3

[ Boiling Point ]:
496.9ºC at 760 mmHg

[ Melting Point ]:
222-224 °C

[ Molecular Formula ]:
C₁₇H₁₉NO₃

[ Molecular Weight ]:
285.33800

[ Flash Point ]:
254.3ºC

[ Exact Mass ]:
285.13600

[ PSA ]:
61.72000

[ LogP ]:
2.86470

[ Vapour Pressure ]:
1.69E-10mmHg at 25°C

[ Index of Refraction ]:
1.62

Safety Information

[ HS Code ]:
2933499090

Customs

[ HS Code ]: 2933499090

[ Summary ]:
2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Related Compounds

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