2-di-1-asp

Modify Date: 2024-01-04 12:02:36

2-di-1-asp Structure
2-di-1-asp structure
Common Name 2-di-1-asp
CAS Number 2156-29-8 Molecular Weight 366.24000
Density 1.091g/cm3 Boiling Point 397.8℃at 760 mmHg
Molecular Formula C16H19IN2 Melting Point 280ºC (dec.)(lit.)
MSDS USA Flash Point 179.3℃
Symbol GHS07
GHS07
Signal Word Warning

 Use of 2-di-1-asp


2-Di-1-ASP (Compound 18a) is a mono-stryryl dye, and widely used as mitochondrial stain and groove-binding fluorescent probes for double-stranded DNA. 2-Di-1-ASP is selective for G-quadruplex (G4) and double-stranded DNA[1].

 Names

Name 2-[4-(dimethylamino)styryl]-1-methylpyridinium iodide
Synonym More Synonyms

 2-di-1-asp Biological Activity

Description 2-Di-1-ASP (Compound 18a) is a mono-stryryl dye, and widely used as mitochondrial stain and groove-binding fluorescent probes for double-stranded DNA. 2-Di-1-ASP is selective for G-quadruplex (G4) and double-stranded DNA[1].
Related Catalog
In Vitro 2-Di-1-ASP (Compound 18a) displays significant fluorescence enhancements in the presence of G-quadruplex (G4) structures (up to 300-fold), and good selectivity with respect to double-stranded DNA. 2-Di-1-ASP shows fluorimetric selectivity for parallel G4-DNA forms (c-kit2, c-kit87up, c-myc)[1].
References

[1]. Xie X, et al. Identification of optimal fluorescent probes for G-quadruplex nucleic acids through systematic exploration of mono- and distyryl dye libraries. Beilstein J Org Chem. 2019 Aug 6;15:1872-1889.

 Chemical & Physical Properties

Density 1.091g/cm3
Boiling Point 397.8℃at 760 mmHg
Melting Point 280ºC (dec.)(lit.)
Molecular Formula C16H19IN2
Molecular Weight 366.24000
Flash Point 179.3℃
Exact Mass 366.05900
PSA 7.12000
Vapour Pressure 1.55E-06mmHg at 25°C
Index of Refraction 1.668
Water Solubility DMSO: soluble

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H315-H319-H335
Precautionary Statements P261-P305 + P351 + P338
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xi: Irritant;
Risk Phrases R36/37/38
Safety Phrases 26-36
RIDADR NONH for all modes of transport
WGK Germany 3

 Articles32

More Articles
In silico activity profiling reveals the mechanism of action of antimalarials discovered in a high-throughput screen.

Proc. Natl. Acad. Sci. U. S. A. 105 , 9059-64, (2008)

The growing resistance to current first-line antimalarial drugs represents a major health challenge. To facilitate the discovery of new antimalarials, we have implemented an efficient and robust high-...

Distribution pattern of viable mitochondria in bovine lens epithelial cells.

Dev. Ophthalmol. 26 , 90-6, (1994)

Live-cell imaging of the cytoskeleton and mitochondrial-cytoskeletal interactions in budding yeast.

Methods Mol. Biol. 586 , 41-68, (2009)

This chapter describes labeling methods and optical approaches for live-cell imaging of the cytoskeleton and of a specific organelle-cytoskeleton interaction in budding yeast.

 Synonyms

D-308
2-{2-[4-(dimethylamino)phenyl]ethenyl}-1-methylpyridinium iodide
2m2Pm
2-(4-(Dimethylamino)styryl)-N-methylpyridinium
MFCD00011980
o-DPD
2-<4-(dimethylamino)styryl>-1-ethylpyridinium iodide
2-(4-(dimethylamino)styryl)-1-methylpyridinium
(E)-2-(4-(dimethylamino)styryl)-1-methylpyridinium iodide
2-(4-DIMETHYLAMINOSTYRYL)-1-METHYLPYRIDINIUM IODIDE
2-DI-1-ASP
EINECS 218-460-8
1-METHYL-2-P-DIMETHYLAMINO-STYRYL-PYRIDINIUM-IODIDE