(S)-Willardiine
Modify Date: 2024-01-11 18:58:58
(S)-Willardiine structure
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Common Name | (S)-Willardiine | ||
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| CAS Number | 21416-43-3 | Molecular Weight | 199.16400 | |
| Density | 1.501 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C7H9N3O4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of (S)-Willardiine(S)-Willardiine is a potent agonist of AMPA/kainate receptors with EC50 of 44.8 uM.IC50 value: 44.8 uM(EC50) [1]Target: AMPA/kainate receptor agonistin vitro: The (S)- but not (R)-isomers of willardiine and 5-bromowillardiine were potent agonists, producing rapidly but incompletely desensitizing responses [1]. At a concentration of 1.8 mM, Ca2+ inhibited the currents induced by 100 microM willardiine by approximately 50% [2].in vivo: In newborn mice (P5, histopathology at P10), local injection of the AMPA receptor agonist S-bromo-willardiine at day 5 after birth induced cortical damage and white matter damage, which was reduced in a dose-dependent manner by the AMPA receptor antagonists [3]. |
| Name | 3-(uracil-1-yl)-L-alanine |
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| Synonym | More Synonyms |
| Description | (S)-Willardiine is a potent agonist of AMPA/kainate receptors with EC50 of 44.8 uM.IC50 value: 44.8 uM(EC50) [1]Target: AMPA/kainate receptor agonistin vitro: The (S)- but not (R)-isomers of willardiine and 5-bromowillardiine were potent agonists, producing rapidly but incompletely desensitizing responses [1]. At a concentration of 1.8 mM, Ca2+ inhibited the currents induced by 100 microM willardiine by approximately 50% [2].in vivo: In newborn mice (P5, histopathology at P10), local injection of the AMPA receptor agonist S-bromo-willardiine at day 5 after birth induced cortical damage and white matter damage, which was reduced in a dose-dependent manner by the AMPA receptor antagonists [3]. |
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| Related Catalog | |
| References |
| Density | 1.501 g/cm3 |
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| Molecular Formula | C7H9N3O4 |
| Molecular Weight | 199.16400 |
| Exact Mass | 199.05900 |
| PSA | 118.18000 |
| Index of Refraction | 1.543 |
| HS Code | 2933599090 |
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(S)-Willardiine CAS#:21416-43-3 |
| Literature: Murakoshi, Isamu; Ikegami, Fumio; Yoneda, Yoshihiro; Ihara, Harumi; Sakata, Kumiko; Koide, Chiharu Chemical & Pharmaceutical Bulletin, 1986 , vol. 34, # 4 p. 1473 - 1478 |
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(S)-Willardiine CAS#:21416-43-3 |
| Literature: Jane, David E.; Hoo, Ken; Kamboj, Raj; Deverill, Michele; Bleakman, David; Mandelzys, Allan Journal of Medicinal Chemistry, 1997 , vol. 40, # 22 p. 3645 - 3650 |
| HS Code | 2933599090 |
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| Summary | 2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
| S(-)-α-AMINO-3,4-DIHYDRO-2,4-DIOXO-1(2H)-PYRIMIDINEPROPANOIC ACID |
| S(−)-Willardiine |
| S()-Willardiine |
| (S)-Willardiine |