Pomalidomide-PEG4-COOH

Modify Date: 2024-04-06 21:08:41

Pomalidomide-PEG4-COOH Structure
Pomalidomide-PEG4-COOH structure
Common Name Pomalidomide-PEG4-COOH
CAS Number 2138440-81-8 Molecular Weight 521.517
Density 1.4±0.1 g/cm3 Boiling Point 773.6±60.0 °C at 760 mmHg
Molecular Formula C24H31N3O10 Melting Point N/A
MSDS N/A Flash Point 421.6±32.9 °C

 Use of Pomalidomide-PEG4-COOH


Pomalidomide-PEG4-COOH is a E3 ligase ligand-linker conjugate. Pomalidomide-PEG4-COOH contains the Pomalidomide based cereblon ligand and 4-unit PEG linker used in PROTAC technology (extracted from patent WO2017184995A1)[1].

 Names

Name Pomalidomide-PEG4-CO2H
Synonym More Synonyms

 Pomalidomide-PEG4-COOH Biological Activity

Description Pomalidomide-PEG4-COOH is a E3 ligase ligand-linker conjugate. Pomalidomide-PEG4-COOH contains the Pomalidomide based cereblon ligand and 4-unit PEG linker used in PROTAC technology (extracted from patent WO2017184995A1)[1].
Related Catalog
References

[1]. Guangrong Zheng, et al.Compounds that induce degradation of anti-apoptotic bcl-2 family proteins and the uses thereof. Patent WO2017184995A1.

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Boiling Point 773.6±60.0 °C at 760 mmHg
Molecular Formula C24H31N3O10
Molecular Weight 521.517
Flash Point 421.6±32.9 °C
Exact Mass 521.200928
LogP -1.75
Vapour Pressure 0.0±2.8 mmHg at 25°C
Index of Refraction 1.589

 Synonyms

3,6,9,12-Tetraoxapentadecan-15-oic acid, 1-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]-
1-{[2-(2,6-Dioxo-3-piperidinyl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]amino}-3,6,9,12-tetraoxapentadecan-15-oic acid
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