Pomalidomide-PEG4-COOH

Names

[ Name ]:
Pomalidomide-PEG4-COOH

[Synonym ]:
3,6,9,12-Tetraoxapentadecan-15-oic acid, 1-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]-
1-{[2-(2,6-Dioxo-3-piperidinyl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]amino}-3,6,9,12-tetraoxapentadecan-15-oic acid

Biological Activity

[Description]:

Pomalidomide-PEG4-COOH is a E3 ligase ligand-linker conjugate. Pomalidomide-PEG4-COOH contains the Pomalidomide based cereblon ligand and 4-unit PEG linker used in PROTAC technology (extracted from patent WO2017184995A1)[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> PROTAC >> Ligand for E3 Ligase

[References]

[1]. Guangrong Zheng, et al.Compounds that induce degradation of anti-apoptotic bcl-2 family proteins and the uses thereof. Patent WO2017184995A1.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
773.6±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₄H₃₁N₃O₁₀

[ Molecular Weight ]:
521.517

[ Flash Point ]:
421.6±32.9 °C

[ Exact Mass ]:
521.200928

[ LogP ]:
-1.75

[ Vapour Pressure ]:
0.0±2.8 mmHg at 25°C

[ Index of Refraction ]:
1.589