2-amino-9-[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-8-methylsulfanyl-3H-purin-6-one

Modify Date: 2025-08-26 15:53:29

2-amino-9-[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-8-methylsulfanyl-3H-purin-6-one structure	Common Name	2-amino-9-[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-8-methylsulfanyl-3H-purin-6-one
	CAS Number	2104-66-7	Molecular Weight	329.33
	Density	2.12g/cm3	Boiling Point	757.3ºC at 760 mmHg
	Molecular Formula	C₁₁H₁₅N₅O₅S	Melting Point	N/A
	MSDS	N/A	Flash Point	411.8ºC

Use of 2-amino-9-[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-8-methylsulfanyl-3H-purin-6-one

8-(Methylthio)guanosine is a guanosine analogue. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7)[1].

Name	4-(4-chloroanilino)-4-oxobutanoic acid
Synonym	More Synonyms

Description	8-(Methylthio)guanosine is a guanosine analogue. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7)[1].
Related Catalog	Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog Research Areas >> Others
References	[1]. Lee J, et al. Molecular basis for the immunostimulatory activity of guanine nucleoside analogs: activation of Toll-like receptor 7. Proc Natl Acad Sci U S A. 2003 May 27;100(11):6646-51.

Density	2.12g/cm3
Boiling Point	757.3ºC at 760 mmHg
Molecular Formula	C₁₁H₁₅N₅O₅S
Molecular Weight	329.33
Flash Point	411.8ºC
Exact Mass	329.07900
PSA	184.81000
Vapour Pressure	4.18E-24mmHg at 25°C
Index of Refraction	1.915

Guanosine,7,8-d...

CAS#:26001-38-7

Dimethyl sulfate

CAS#:77-78-1

~63%

2-amino-9-[3,4-...

CAS#:2104-66-7

Literature: Giorgi, Tatiana; Lena, Stefano; Mariani, Paolo; Cremonini, Mauro A.; Masiero, Stefano; Pieraccini, Silvia; Rabe, Juergen P.; Samori, Paolo; Spada, Gian Piero; Gottarelli, Giovanni Journal of the American Chemical Society, 2003 , vol. 125, # 48 p. 14741 - 14749

8-Bromoguanosine

CAS#:4016-63-1

2-amino-9-[3,4-...

CAS#:2104-66-7

Literature: Lin; Cheng; Ishiguro; Sartorelli Journal of Medicinal Chemistry, 1985 , vol. 28, # 9 p. 1194 - 1198

Precursor 3
CAS#:26001-38-7 Guanosine,7,8-d... CAS#:77-78-1 Dimethyl sulfate CAS#:4016-63-1 8-Bromoguanosine
DownStream 0

8-methylsulfanyl-guanosine

8-Methylmercapto-guanosin

8-Methylthioguanosin

8-methylthioguanosine

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2-amino-9-[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-8-methylsulfanyl-3H-purin-6-one

Use of 2-amino-9-[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-8-methylsulfanyl-3H-purin-6-one

Names

Biological Activity

Chemical & Physical Properties

Synthetic Route

Precursor & DownStream

Synonyms

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.