Z-VDVAD-FMK

Modify Date: 2024-01-09 11:23:30

Z-VDVAD-FMK structure	Common Name	Z-VDVAD-FMK
	CAS Number	210344-92-6	Molecular Weight	695.73
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₃₂H₄₆FN₅O₁₁	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Z-VDVAD-FMK

Z-VDVAD-FMK is a special inhibitor of caspase-2. Z-VDVAD-FMK produces a reduction in Lovastatin-induced apoptosis[1][3][3].

Name	methyl 5-fluoro-3-[2-[[2-[[4-methoxy-2-[[3-methyl-2-(phenylmethoxycarbonylamino)butanoyl]amino]-4-oxobutanoyl]amino]-3-methylbutanoyl]amino]propanoylamino]-4-oxopentanoate
Synonym	More Synonyms

Description	Z-VDVAD-FMK is a special inhibitor of caspase-2. Z-VDVAD-FMK produces a reduction in Lovastatin-induced apoptosis[1][3][3].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Apoptosis >> Caspase
Target	Caspase-2
In Vitro	"Cotreatment of cells with the caspase inhibitors Ac-DEVD-CHO, Z-VDVAD-FMK (100μM), Z-IETD-fmk, and Z-LEHD-fmk alone or in combination, or overexpression of CrmA, prevents many morphological features of apoptosis but not loss of mitochondrial membrane potential (DCm), phospatidilserine exposure, and cell death[1]. Z-VDVAD-FMK (2 μM) greatly inhibits the Rho-kinase activity in HMEC-1 cells stimulated by Thrombin and displays no effect on control cells[2]. Z-VDVAD-FMK (zVDVAD-fmk) produces a reduction in Lovastatin-induced apoptosis. Z-VDVAD-FMK (100 μM) significantly reduces Lovastatin-induced loss of DNA by 19.1±8.3%[3]." Cell Viability Assay[1] Cell Line: The human T-cell leukemia Jurkat (Clone E6.1, ATCC TIB-152) Concentration: 100 μM Incubation Time: 22 hours Result: Prevented Doxorubicin (1 μM)-induced nuclear apoptosis, but not cell death.
References	[1]. S Gamen, et al. Doxorubicin treatment activates a Z-VAD-sensitive caspase, which causes deltapsim loss, caspase-9 activity, and apoptosis in Jurkat cells. Exp Cell Res. 2000 Jul 10;258(1):223-35. [2]. Cédric Sapet, et al. Thrombin-induced endothelial microparticle generation: identification of a novel pathway involving ROCK-II activation by caspase-2. Blood. 2006 Sep 15;108(6):1868-76. [3]. Simon W Rabkin, et al. Lovastatin-induced cardiac toxicity involves both oncotic and apoptotic cell death with the apoptotic component blunted by both caspase-2 and caspase-3 inhibitors. Toxicol Appl Pharmacol. 2003 Dec 15;193(3):346-55.

Molecular Formula	C₃₂H₄₆FN₅O₁₁
Molecular Weight	695.73
Exact Mass	695.31800
PSA	241.85000
LogP	3.78290

Z-Val-Asp(OMe)-Val-Ala-Asp(OMe)-Fluoromethylketone

FK016

Z-Val-Asp(OMe)-Val-Ala-Asp(OMe)-FMK

Z-VD(OMe)VAD(OMe)-FMK

DC Chemicals Limited
China
Product Name: Z-VDVAD-FMK
Price: $Inquiry/1g
Purity: 98.0%
Stocking Period: 1 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Z-VDVAD-FMK
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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