1381885-28-4

1381885-28-4 structure

Name: Z-VRPR-FMK(Z-Val-Arg-Pro-DL-Arg-FMK
Chemical Name: S-[2,3-Bis(palmitoyloxy)propyl]-L-cysteinylglycyl-L-α-aspartyl-L-prolyl-L-lysyl-L-histidyl-L-prolyl-L-lysyl-L-seryl-L-phenylalanine
CAS Number: 1381885-28-4
Molecular Formula: C₈₄H₁₄₀N₁₄O₁₈S
Molecular Weight: 1666.158
Catalog: Signaling Pathways NF-κB MALT1
Create Date: 2018-06-26 13:00:46
Modify Date: 2024-01-10 16:47:46
Z-VRPR-FMK is an irreversible MALT1 protein inhibitor. Z-VRPR-FMK inhibits the growth and invasion of diffuse large B-cell lymphoma by inhibiting MALT1-induced NF-κB activation and MMP expression[1].

Name	S-[2,3-Bis(palmitoyloxy)propyl]-L-cysteinylglycyl-L-α-aspartyl-L-prolyl-L-lysyl-L-histidyl-L-prolyl-L-lysyl-L-seryl-L-phenylalanine
Synonyms	L-Phenylalanine, S-[2,3-bis[(1-oxohexadecyl)oxy]propyl]-L-cysteinylglycyl-L-α-aspartyl-L-prolyl-L-lysyl-L-histidyl-L-prolyl-L-lysyl-L-seryl- S-[2,3-Bis(palmitoyloxy)propyl]-L-cysteinylglycyl-L-α-aspartyl-L-prolyl-L-lysyl-L-histidyl-L-prolyl-L-lysyl-L-seryl-L-phenylalanine

Description	Z-VRPR-FMK is an irreversible MALT1 protein inhibitor. Z-VRPR-FMK inhibits the growth and invasion of diffuse large B-cell lymphoma by inhibiting MALT1-induced NF-κB activation and MMP expression[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> NF-κB >> MALT1
In Vitro	Z-VRPR-FMK(50 μM, 24 h)可以有效降低 HBL-1 细胞核 c-REL 水平，抑制了 NF-κB 的信号传导[2]。 Z-VRPR-FMK(50 μM, 48 h)对 ABC-DLBCL 细胞系 HBL-1, TMD8, OCI-Ly3 和 OCI-Ly10 具有一定的抑制增殖作用[2]。
References	[1]. Jianglong Feng, et al. Z-VRPR-FMK can inhibit the growth and invasiveness of diffuse large B-cell lymphoma by depressing NF-κB activation and MMP expression induced by MALT1. Int J Clin Exp Pathol. 2019 Jun 1;12(6):1947-1955. [2]. Lorena Fontan, et al. MALT1 small molecule inhibitors specifically suppress ABC-DLBCL in vitro and in vivo. Cancer Cell. 2012 Dec 11;22(6):812-24.