GSK-LSD1 Dihydrochloride structure
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Common Name | GSK-LSD1 Dihydrochloride | ||
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CAS Number | 2102933-95-7 | Molecular Weight | 289.24 | |
Density | N/A | Boiling Point | N/A | |
Molecular Formula | C14H22Cl2N2 | Melting Point | N/A | |
MSDS | N/A | Flash Point | N/A |
Use of GSK-LSD1 DihydrochlorideGSK-LSD1 Dihydrochloride is a potent, selective and irreversible lysine specific demethylase 1 (LSD1) inhibitor with an IC50 of 16 nM. |
Name | GSK-LSD1 Dihydrochloride |
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Description | GSK-LSD1 Dihydrochloride is a potent, selective and irreversible lysine specific demethylase 1 (LSD1) inhibitor with an IC50 of 16 nM. |
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Related Catalog | |
Target |
IC50: 16 nM (LSD1)[1] |
In Vitro | GSK-LSD1 Dihydrochloride shows more than 1000 fold selectivity over other closely related FAD utilizing enzymes including LSD2, and monoamine oxidases MAO-A, MAO-B[1]. GSK-LSD1 can inhibit KDM1A/LSD1 enzyme activity. GSK-LSD1 induces the formation of LC3-II in U2OS cells. The electronic microscopy shows the formation of autophagosome with GSK-LSD1 treatment. GSK-LSD1 potently inhibits proliferation of varies cancer cell lines by changing gene expression patterns[2]. |
References |
Molecular Formula | C14H22Cl2N2 |
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Molecular Weight | 289.24 |
Storage condition | 2-8℃ |