GSK-LSD1 2HCL

Modify Date: 2025-08-31 19:47:30

GSK-LSD1 2HCL Structure
GSK-LSD1 2HCL structure
Common Name GSK-LSD1 2HCL
CAS Number 1431368-48-7 Molecular Weight 216.322
Density 1.1±0.1 g/cm3 Boiling Point 347.4±42.0 °C at 760 mmHg
Molecular Formula C14H20N2 Melting Point N/A
MSDS N/A Flash Point 206.0±19.7 °C

 Use of GSK-LSD1 2HCL


GSK-LSD1 is a LSD1 inhibitor. GSK-LSD1 reduces food intake and body weight, and improves insulin sensitivity and glycemic control in mouse models of obesity. GSK-LSD1 also ameliorates NAFLD. GSK-LSD1 inhibits SARS-CoV-2-triggered cytokine release in COVID-19 PBMCs. GSK-LSD1 also inhibits cancer growth and metastasis[1][2][3].

 Names

Name N-[(1R,2S)-2-Phenylcyclopropyl]-4-piperidinamine
Synonym More Synonyms

 GSK-LSD1 2HCL Biological Activity

Description GSK-LSD1 is a LSD1 inhibitor. GSK-LSD1 reduces food intake and body weight, and improves insulin sensitivity and glycemic control in mouse models of obesity. GSK-LSD1 also ameliorates NAFLD. GSK-LSD1 inhibits SARS-CoV-2-triggered cytokine release in COVID-19 PBMCs. GSK-LSD1 also inhibits cancer growth and metastasis[1][2][3].
Related Catalog
References

[1]. Ramms B, et al. Systemic LSD1 Inhibition Prevents Aberrant Remodeling of Metabolism in Obesity. Diabetes. 2022 Dec 1;71(12):2513-2529.  

[2]. Hong KS, et al. GSK-LSD1, an LSD1 inhibitor, quashes SARS-CoV-2-triggered cytokine release syndrome in-vitro. Signal Transduct Target Ther. 2020 Nov 17;5(1):267.  

[3]. Alsaqer SF, et al. Inhibition of LSD1 epigenetically attenuates oral cancer growth and metastasis. Oncotarget. 2017 Jul 27;8(43):73372-73386.  

 Chemical & Physical Properties

Density 1.1±0.1 g/cm3
Boiling Point 347.4±42.0 °C at 760 mmHg
Molecular Formula C14H20N2
Molecular Weight 216.322
Flash Point 206.0±19.7 °C
Exact Mass 216.162643
LogP 1.63
Appearance of Characters white to beige
Vapour Pressure 0.0±0.8 mmHg at 25°C
Index of Refraction 1.580
Storage condition 2-8°C
Water Solubility H2O: soluble20mg/mL, clear

 Synonyms

N-[(1R,2S)-2-Phenylcyclopropyl]-4-piperidinamine
4-Piperidinamine, N-[(1R,2S)-2-phenylcyclopropyl]-
GSK-LSD1 2HCL
GSK-LSD1 (hydrochloride)
LSD1 inhibitor
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