Decanoyl-RVKR-CMK TFA

Modify Date: 2025-08-25 19:46:59

Decanoyl-RVKR-CMK TFA structure	Common Name	Decanoyl-RVKR-CMK TFA
	CAS Number	2098497-25-5	Molecular Weight	858.43
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₃₆H₆₇ClF₃N₁₁O₇	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Decanoyl-RVKR-CMK TFA

Decanoyl-RVKR-CMK (DecRVKRcmk) TFA inhibits over-expressed gp160 processing and HIV-1 replication[1].

Name	Decanoyl-RVKR-CMK TFA

Description	Decanoyl-RVKR-CMK (DecRVKRcmk) TFA inhibits over-expressed gp160 processing and HIV-1 replication[1].
Related Catalog	Signaling Pathways >> Anti-infection >> HIV Research Areas >> Infection Research Areas >> Inflammation/Immunology
In Vitro	Decanoyl-RVKR-CMK (DecRVKRcmk) TFA inhibits HIV-2ROD replication by blocking envelope glycoprotein precursor processing in the Jurkat lymphocyte cell[1]. Decanoyl-RVKR-CMK (DecRVKRcmk) TFA blocks regulated secretion of VGF[2]. Cell Viability Assay[1] Cell Line: HeLaCD4 cells infected with recombinant vaccinia viruses at a multiplicity of infection (MOI) of 5 PFU/mL Concentration: 35 and 70 µΜ Incubation Time: 7 days Result: Peptide at 35 µM significantly inhibited ex vivo HIV-1 and HIV-2 replications (70-80% inhibition).
References	[1]. B Bahbouhi, et al. Inhibition of HIV-2(ROD) replication in a lymphoblastoid cell line by the alpha1-antitrypsin Portland variant (alpha1-PDX) and the decRVKRcmk peptide: comparison with HIV-1(LAI). Microbes Infect. 2001 Nov;3(13):1073-84. [2]. Angelo L Garcia, et al. A prohormone convertase cleavage site within a predicted alpha-helix mediates sorting of the neuronal and endocrine polypeptide VGF into the regulated secretory pathway. J Biol Chem. 2005 Dec 16;280(50):41595-608.

Molecular Formula	C₃₆H₆₇ClF₃N₁₁O₇
Molecular Weight	858.43

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