Decanoyl-RVKR-CMK

Modify Date: 2025-08-23 21:44:41

Use of Decanoyl-RVKR-CMK

Decanoyl-RVKR-CMK (DecRVKRcmk) inhibits over-expressed gp160 processing and HIV-1 replication[1].

Name	Furin Convertase Inhibitor ( Chloromethylketone)
Synonym	More Synonyms

Description	Decanoyl-RVKR-CMK (DecRVKRcmk) inhibits over-expressed gp160 processing and HIV-1 replication[1].
Related Catalog	Signaling Pathways >> Anti-infection >> HIV Research Areas >> Infection Research Areas >> Inflammation/Immunology
In Vitro	Decanoyl-RVKR-CMK (DecRVKRcmk) inhibits HIV-2ROD replication by blocking envelope glycoprotein precursor processing in the Jurkat lymphocyte cell[1].Decanoyl-RVKR-CMK (DecRVKRcmk) blocks regulated secretion of VGF[2]. Cell Viability Assay Cell Line: HeLaCD4 cells infected with recombinant vaccinia viruses at a multiplicity of infection (MOI) of 5 PFU/mL[1]. Concentration: 35 and 70 µΜ. Incubation Time: 7 days. Result: Peptide at 35 µM significantly inhibited ex vivo HIV-1 and HIV-2 replications (70–80% inhibition).
References	[1]. B Bahbouhi, et al. Inhibition of HIV-2(ROD) replication in a lymphoblastoid cell line by the alpha1-antitrypsin Portland variant (alpha1-PDX) and the decRVKRcmk peptide: comparison with HIV-1(LAI). Microbes Infect. 2001 Nov;3(13):1073-84. [2]. Angelo L Garcia, et al. A prohormone convertase cleavage site within a predicted alpha-helix mediates sorting of the neuronal and endocrine polypeptide VGF into the regulated secretory pathway. J Biol Chem. 2005 Dec 16;280(50):41595-608.

decanoyl RVKR-CMK

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decanoyl-Arg-Val-Lys-Arg-chloromethylketone

Decanoic acid,4-formyl-2-methoxyphenyl ester

L-Lysinamide, N-(diaminomethylene)-N-(1-oxodecyl)-L-ornithyl-L-valyl-N-[(1S)-1-(2-chloroacetyl)-4-[(diaminomethylene)amino]butyl]-

4-formyl-2-methoxyphenyl decanoate

decanoyl vanillin

decanoyl-RVKR-chloromethylketone

Dec-RVKR-CMK

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