Lu AF27139
Modify Date: 2024-01-06 17:28:51
Lu AF27139 structure
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Common Name | Lu AF27139 | ||
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| CAS Number | 2097117-06-9 | Molecular Weight | 497.9212 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C21H19ClF3N5O2S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Lu AF27139Lu AF27139 is a novel rodent-active and CNS-penetrant P2X7 receptor antagonist. Lu AF27139 is highly selective and potent against rat, mouse, and human forms of the receptors. The rat pharmacokinetic profile is favorable with high oral bioavailability, modest clearance (0.79 L/(h kg)), and good CNS permeability. Importantly, Lu AF27139 was without effect in standard in vitro and in vivo toxicity studies. Lu AF27139 is a valuable tool for probing the role of the P2X7 receptor in rodent models of CNS diseases. |
| Name | Lu AF27139 |
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| Description | Lu AF27139 is a novel rodent-active and CNS-penetrant P2X7 receptor antagonist. Lu AF27139 is highly selective and potent against rat, mouse, and human forms of the receptors. The rat pharmacokinetic profile is favorable with high oral bioavailability, modest clearance (0.79 L/(h kg)), and good CNS permeability. Importantly, Lu AF27139 was without effect in standard in vitro and in vivo toxicity studies. Lu AF27139 is a valuable tool for probing the role of the P2X7 receptor in rodent models of CNS diseases. |
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| Molecular Formula | C21H19ClF3N5O2S |
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| Molecular Weight | 497.9212 |