2097117-06-9
2097117-06-9 structure
- Name: Lu AF27139
- Chemical Name: Lu AF27139
- CAS Number: 2097117-06-9
- Molecular Formula: C21H19ClF3N5O2S
- Molecular Weight: 497.9212
- Catalog: Signaling Pathways Membrane Transporter/Ion Channel P2X Receptor
- Create Date: 2021-12-20 14:33:19
- Modify Date: 2024-01-06 17:28:51
-
Lu AF27139 is a novel rodent-active and CNS-penetrant P2X7 receptor antagonist. Lu AF27139 is highly selective and potent against rat, mouse, and human forms of the receptors. The rat pharmacokinetic profile is favorable with high oral bioavailability, modest clearance (0.79 L/(h kg)), and good CNS permeability. Importantly, Lu AF27139 was without effect in standard in vitro and in vivo toxicity studies. Lu AF27139 is a valuable tool for probing the role of the P2X7 receptor in rodent models of CNS diseases.
| Name | Lu AF27139 |
|---|
| Description | Lu AF27139 is a novel rodent-active and CNS-penetrant P2X7 receptor antagonist. Lu AF27139 is highly selective and potent against rat, mouse, and human forms of the receptors. The rat pharmacokinetic profile is favorable with high oral bioavailability, modest clearance (0.79 L/(h kg)), and good CNS permeability. Importantly, Lu AF27139 was without effect in standard in vitro and in vivo toxicity studies. Lu AF27139 is a valuable tool for probing the role of the P2X7 receptor in rodent models of CNS diseases. |
|---|
| Molecular Formula | C21H19ClF3N5O2S |
|---|---|
| Molecular Weight | 497.9212 |